ID A0A1V4KG92_PATFA Unreviewed; 883 AA.
AC A0A1V4KG92;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Desmocollin-1 {ECO:0000313|EMBL:OPJ83401.1};
GN Name=DSC2 {ECO:0000313|EMBL:OPJ83401.1};
GN ORFNames=AV530_006302 {ECO:0000313|EMBL:OPJ83401.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ83401.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ83401.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ83401.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ83401.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ83401.1}.
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DR EMBL; LSYS01003169; OPJ83401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4KG92; -.
DR STRING; 372326.A0A1V4KG92; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24027:SF80; CADHERIN-13; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..883
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012347228"
FT TRANSMEM 682..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..236
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 237..348
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 349..465
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 466..571
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 883 AA; 98046 MW; 4BE4E06C8E40EBCC CRC64;
MVPAAPRLVL GLLVLSLCCE ACKKVTFRVP SELEADTLVG RVDLKECLPS AEFISSTDGN
FKILEDGSVY TTSTLSLSAE RKNFTILLND IQEHVQKKIH VSLVKEEKKT QAERTRHARD
TVLKRTKRRW GPIPSVMIEN SLGPFPLQIQ QVQSDTAQNY TIYYSASGPG IDQDPKGLFY
IERETGNIFA TRAVDREQYP SFQIICFATT PDGYSPEVPL VHTIRIEDDN DNAPYFTQDL
FEFSVPENSK PGIIVGKVTA EDKDEPYTLH TALKYRIVSQ NPPIPPVFSL HGDTGVISVA
SPQLDREVES GYLLLIEARD MAGQPFGLCT TGTVTVRIED TNDNAPSFRQ TQYEVRVEEN
RVNVEILRIA VVDLDEPRSP ASRAVFEIIR GNDDRSFEIT TDRNTNEGVL CVVKGLDYET
AKQRVLVIAV NNEAPYMLAP HSQQVSQSTS SVTVYVIDVD EGPVFKPCLL RIDVKECEDI
GTSIGRYVAE DPETGNSEGI CYRIAPGQCN WISIDEKSGE VRTIRVLDRD VAEMRQGQCN
ITVLAIDRNG KTGTGTIQVV IQPGNKNYPR ILKTDYVMCR DRKPICLTAQ DGDASPYSTP
FVYRITDRNL ASSWKITRHN DNSVYLSPKG DIPFGIYDIP VSVTDNGGKV GETHVKVNYC
DCMTPTECSG NTRELREGSV TLGIWAILAM ILGSLLLLLI LITICGCCGT GVMHRHVTDD
CANHNLIISN TEAPGEEVMD HNIIPLQTTT DQGGYGIKTG DQQTFESVKG RGHTLESVKG
GGHQTLGSVK EGGGQTMMDT CRYSYSEWHN FTHPRLGEKV HLCRQDEEQK HSEDYLLSYH
YEGKGSLAGS VGCCSDQHEE EALDFLDQLE PKFRTLAEAC VKR
//
