ID A0A1V4KLI1_PATFA Unreviewed; 1866 AA.
AC A0A1V4KLI1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN5A {ECO:0000313|EMBL:OPJ85265.1};
GN ORFNames=AV530_011715 {ECO:0000313|EMBL:OPJ85265.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ85265.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ85265.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ85265.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ85265.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ85265.1}.
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DR EMBL; LSYS01002888; OPJ85265.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4KLI1; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:OPJ85265.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 125..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 386..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 627..651
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 672..705
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 760..785
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1057..1075
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1096..1112
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1124..1143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1188..1208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1298..1321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1380..1398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1410..1432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1444..1463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1511..1533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1600..1623
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..420
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 560..791
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 799..1051
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1055..1330
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1379..1633
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 459..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 480..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1866 AA; 213302 MW; 09B87E8A8084C599 CRC64;
MADFLLPPGT NSFHRFTPES LAAIEKRIAE KLARNAKQEY REQLGEEEKP QPQFDLQACK
KLPDIYGTVP PELIGEPLED LDPFYNDRKT FIVLNKGKTI FRFSATPALY ILSPFHPIRR
AAIKILVHSL FSMFIMCTIL TNCVFMAQSE TPSWNKYVEY TFTGIYTFES LIKILARGFC
MTEFTFLRDP WNWLDFSVIV MAYITEFVDL GNVSALRTFR VLRALKTISV ISGLKTIVGA
LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGNLRHKCVR DYTKFNFTNG TLYLDGRMWN
TSEEFLSDPV NYFIKNGTED VLLCGNSTDA GTCPEGYICL KAGENPDHGY TSFDTFGWAF
LSLFRLMTQD CWERLYQQTL RSAGKIYMLF FMLVIFLGSF YLVNLILAVV AMAYEEQNQA
TIAETEEKER KFREAMEMLK KEQEALAAKG IDSMSLSSLE MSPSASKNAK ERRNRRKKKK
SLGTEEYGED QKNPKCDYDD SQRRMTSPSD EASKKQLLMT HRPSVDHSDE PFQRQRAVSA
VSIITSALEE LEESHQKCPP CWNHFAVKFL IWDCCPLXXX XHYKMTKEFD HMLYIGNLVF
TGIFTAEMIF KVIALDPYYY FQQGWNIFDS IIVILSLMEL GLSSMGNLSV LRSFRLLRVF
KLAKSWPTLN TLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYM DNVKKISTTG
NLPRWHMNDF FHSFLIIFRI LCGEWIETMW DCMEVAGQPL CLLVFLLVMV IGNLVVLNLF
LALLLSSFSA DNLSAPDEDG EMNNLQLAFA RINRGLQYVK RTTWNFCCSV LRHPKTTAEK
KAMMKLAAQN TGALNNCMNS HTTAELGKDM ENHKENHAED GMTKSGEKHL GITDNDDFMT
NPDLSICVPI AVGESDIEEE DEEQSTFTEM EQQDKQLQLR GQRCQSPGVR SQNSEICEEF
NELHMDKQLK AEPPPPVGKT ELDEISLSEG STVDLTNPAE LLEQIPEFAE ELMEPEECFP
EVCVRFFPCC LVDITKFPGK IWWRLRKTCY RIVEHNWFET FIIFMILLSS GALAFEDIYL
EDRKNIKTML DYADKIFTYI FVLEMLLKWV AYGFKKYFTN AWCWLDFLIV DVSLISLIAN
TLGYSEMGPI KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS
IMGVNLFAGK FGKCINKTEG DMPLDPKIIN NMSDCILYNV SGTFYWTKVK VNFDNVGAGY
LALLQVATFK GWMDIMYAAV DSRECEEQPE WESNLYMYLY FVIFIIFGSF FTLNLFIGVI
IDNFNQQKKK LGGQDIFMTE EQKKYYNAMK KLGSKKPQKP IPRPLNKYQG FLFDVVSKQI
FDVSIMILIC LNMVTMMVET DDQSQEKVNI LHKINMLFVA IFTGECIIKM LALRHYYFTN
GWNIFDFVVV ILSIVGTVLS DIIQKYFFSP TLFRVIRLAR IGRILRLIRG AKGIRTLLFA
LMMSLPALFN IGLLLFLVMF IYAIFGMANF AYVKKEHGID DMFNFQTFAN SMLCLFQITT
SAGWDGLLNP ILNTGPPYCD PNLPNANGSK GDCGSPAIGI LFFVTYIIIS FLIVVNMYIA
IILENFSVAT EESTEPLSED DFDMFYEIWE KFDPEATQFI EYSALSDFAD ALSEPLRIAK
PNKIKLIAMD LPMVSGDRIH CLDILFAFTK RVLGESGEMD ALKIQMEEKF MAANPSKISY
EPITTTLRRK QEEVSAIVIQ RAYRRHLFRR SMKQASYLYR HRTFDGSILE DDAPEKEGLI
AFMMNENYGR PIDKSETLSS TSFPPSYDSV TRGTSDNLQL KMTDSSKSDE AIDCLLSPDR
DKESIV
//
