ID A0A1V4KLQ7_PATFA Unreviewed; 885 AA.
AC A0A1V4KLQ7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 03-MAY-2023, entry version 19.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
GN ORFNames=AV530_016061 {ECO:0000313|EMBL:OPJ84737.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ84737.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ84737.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ84737.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ84737.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ84737.1}.
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DR EMBL; LSYS01003057; OPJ84737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4KLQ7; -.
DR STRING; 372326.A0A1V4KLQ7; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 1.10.287.1250; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OPJ84737.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..219
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 226..459
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 470..613
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 641..875
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 885 AA; 98625 MW; B0EDE98984762F22 CRC64;
MFAVHLLAFH FTKLKEDQIK KVDRYLYHLR LSDDVLLDVM TRFQAEMVRG LGRDTNPTAT
VKMLPTFVRS LPDGSEKGEF LAADLGGSQF RAHQVKVFDD GKQSSQLESK FYHLPKEVIQ
GNGAELFDYV AHCLSDFMET NNLKHKKLPL GFTFSFPCKQ TKLDEGVLLG WTKHFKVRGV
QDTDVVSSLR KTLQKHKDID VDVLALVNDT VGTMMTCGYD DPRCEVGLIV GTGTNACYME
EMRHIDLVEG DEGRMCINTE WGAFGDDGAL DDLRTEFDRE LDLGSLNPGK QLFEKMISSL
YLGELVRLIL LKMTKEGLLF NGKVSTALLT KGKIEMKHVS AMEKYKEGLS NTKEILTELN
LCPSEDDCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN KKLLRMRTTV GIDGGLYKTH
PQYAKRLHKV VRRLVPNCDV RFLLSVSGSG KGAAMVTAVA YRLAAQRRKI DAALAPFSLS
LDTLREVKNK MRTELEYGLK RETQASATVK MLPTYVCGTP DGTEKGKFLA LDLGGTNFRV
LLVKIRSGRR RSVQMYNKIF AIPLEIMQGT GEELFDHIVQ CIADFLEYMG IKGARLPLGF
TFSFPCRQAS IDKEFDLDIV AVVNDTVGTM MTCGYEDPNC EIGLIAGTGS NVCYMEDMKN
IEIVEGNEGK MCINTEWGGF GDNGCIDNIR TKYDKEVDEG SLNPGKQRYE KMTSGMYLGE
IVRQILIDLT KQGLLFRGQI SESLRKRGIF ETKFLSQIES DRLALLQVRR ILQQLGLDST
CDDSIIVKEV CGAVSKRAAQ LCGAGLAAIV EKKRENRGVE HLQITVGVDG TLYKLHPHFS
RVLRETVKEL APQCDVTFML SEDGSGKGAA LITAVAKRLH NIGQK
//
