ID   A0A1V4KNJ2_PATFA        Unreviewed;      1033 AA.
AC   A0A1V4KNJ2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN   Name=PITRM1 {ECO:0000313|EMBL:OPJ85347.1};
GN   ORFNames=AV530_011777 {ECO:0000313|EMBL:OPJ85347.1};
OS   Patagioenas fasciata monilis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX   NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ85347.1, ECO:0000313|Proteomes:UP000190648};
RN   [1] {ECO:0000313|EMBL:OPJ85347.1, ECO:0000313|Proteomes:UP000190648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ85347.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:OPJ85347.1};
RA   Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA   Shapiro B.;
RT   "Band-tailed pigeon sequencing and assembly.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OPJ85347.1}.
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DR   EMBL; LSYS01002888; OPJ85347.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V4KNJ2; -.
DR   STRING; 372326.A0A1V4KNJ2; -.
DR   Proteomes; UP000190648; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:OPJ85347.1};
KW   Protease {ECO:0000313|EMBL:OPJ85347.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT   DOMAIN          501..749
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
SQ   SEQUENCE   1033 AA;  116944 MW;  109B1DAD921FC0FE CRC64;
     MWSRYRAAGG LLSRGRSLVQ KSWRWRSVPA DERALQYRVG EQIHGFTVEQ VTAIPELFLT
     AVKLSHDGTG ARYLHVARED SNNLFSIQFR TTPLDSTGVP HILEHTVLCG SQKYPCRDPF
     FKMLNRSLST FMNAFTASDY TLYPFSTQNP KDFQNLLSVY LDAAFFPCLR QLDFWQEGWR
     LEHENPTDPQ TPLVFKGVVF NEMKGAFTDN ERIFAQHLQN KILPDHTYGV VSGGDPLCIP
     DLTWEQLKQF HATHYHPSNS RFFTYGNFPL EQHLKQIHEE ALVKFERIES NTDIPRQKLW
     EKPREHSVTC GLDSFAADPS KQTTVSVSYL LTDITDTFET FTLSLLSSLL VDGPNSPFYK
     ALIESGVGTD FSPDVGFNGS TREAYFSVGL QGIAERDIDT VKQIIARTID EVIVKGFEED
     RIEALLHKIE IQLKHQSTSF GLALTSYIAS CWNQDGDPVE LLKIADKVSR FRQCLKENPT
     FLQEKVKTYF KDNPHRLTLS MSPEKDYHDK QAKLETEKLE KKVKALSEEE KTQIFEKGLE
     LIALQSKPQD TSCLPALKVS DIEPKIPFTV LETTLAADEI PVQYCAQPTN GVVYFRAVSS
     LNTLPEELKP YVPLFCNVIT KMGCGALDYR EQAQKIELKT GGMSVSPHII PDDSHLDVYE
     QGVLFSSLCL DRNLPDMMHL WSEIFNNPRF EEEEHFRVLV KKIAQELSNG VPDCGHLYAS
     IRASKNLTPS GELQEMFSGM DQVKLMKRIA EMSDIKPILR KLPRIKKYLL NSDNIRCSVN
     AAPQQISEVS KEVEKFIKSI GRSKKERKPV RPHVIEKSSE VKPVGSEMLT GLQITRKLVN
     DPTFKPCQMK THFVLPFPVN YVGECIRTVP YTAADYASLR ILAQLMTAKF LHREIREKGG
     AYGGGAKLSH SGIFTFYSYR DPNSLMTLKT FEKAVEWAKS GEFTQQDIDE AKLAVFAAVD
     APIAPSDKGM GHFLYGISDE MKQSHREQLF AVNSDNLVDV SNKYLAAGKS TRGQAVLGPE
     NADITKDPSW VKR
//