ID A0A1V4KRU7_PATFA Unreviewed; 1130 AA.
AC A0A1V4KRU7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin alpha-1 {ECO:0000313|EMBL:OPJ87155.1};
GN Name=ITGA1 {ECO:0000313|EMBL:OPJ87155.1};
GN ORFNames=AV530_015507 {ECO:0000313|EMBL:OPJ87155.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ87155.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ87155.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ87155.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ87155.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ87155.1}.
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DR EMBL; LSYS01001765; OPJ87155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4KRU7; -.
DR STRING; 372326.A0A1V4KRU7; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1091..1115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 1..55
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 137..320
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 440..502
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 520..578
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 582..642
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1130 AA; 125705 MW; 37A2DD583860C219 CRC64;
MTFSGPLEDL FGYTVQQYEN EEGKWVLIGS PLVGQPEKRT GDVYKCPVGR DNQSPCIKLN
LPASTSVPNV VEVKENMTLG TTLVTNPKGG FLACGPLWAY KCGRLHYTTG VCSNVSSTFE
TIEAIAPSVQ ECKTQLDIVI VLDGSNSIYP WESVTAFLNS LLKNMDIGPQ QTQVGIVQYG
QTVVHEFFLN TYSTTEDVMA AATRIRQRGG TQTMTALGID TARKEAFTEA HGARRGVQKV
MVIVTDGESH DNYRLQEVID DCEDENIQRF AIAILGSYSR GNLSTEKFVE EIKSIASKPT
EKHFFNVSDE LALVTIVEAL GERIFALEAT TDQQAASFEM EMSQAGFSAH YSQDWIMLGA
VGAYDWNGTV IMVKDSGISM PTNDTFRDRL SEKNEALAAY LGYTVNSALT PGGVLYIAGQ
PRYNHTGQVV IYKMEGREVQ VLQRLNGEQI GSYFGGVITT IDINRDSFTD LLLVGAPMYM
GTEKEEQGKV YVYSLNKTKF EYQMSLEPIK QTCCSPLKQD TCKVLKNEPC GARFGTAIAA
VKDLNLDGYN DIVIGSPLED DHRGAVYIYH GHGNTISKKY SQRIASGGDG EKVKFFGQSV
HGVMDLNDDG LIDVTIGGLG GAALFWSRDV AEVNVSMQFA PKSINIQQQN CQINKRKTIC
INATICFKTR LKSKEDTFES SLQYWITLDS QRQISRSLFT ESHERKMQKN ITIKDSECIK
HNFYMLDKPD FQDSVRVLLE FNFSDPESGP VLDSNLPNSI SEYIPFTKDC GAKNKCISDL
VLSVKASIAG DSSSPFIVKS RNDKFTIQLS VKNKGDSAYN TRVLVQSSPN IIFAGIEDIQ
KDSCESNHNI TCKVGYPFLK PAEESQWHML FYFSDSEEPP ETLSDNRGHV TIPVKYEVGL
IFVSVFKEHH VIIAANDTIP TAINTTEQIG DEVTLHYRIE KGEHFPMPNL TLQILFPNVT
EAKNTLLYLT ALSYSQNAIC QSSYPVDPLR ISAGKPFVLP KIKEPTKDTI MDCDTYSCAY
IYCALVPSDI YQVNVSLRVW KPTIIKATIH SLTLVAKALL RSENSSLILR NDHQKVETMI
KISKELPPGT VPLWVILLSI FAGLLILALL IFALWKAGFF KRPLKKKMEK
//
