ID A0A1V4KVI8_PATFA Unreviewed; 817 AA.
AC A0A1V4KVI8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SH3 and PX domain-containing protein 2B isoform C {ECO:0000313|EMBL:OPJ87947.1};
GN Name=SH3PXD2B {ECO:0000313|EMBL:OPJ87947.1};
GN ORFNames=AV530_008007 {ECO:0000313|EMBL:OPJ87947.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ87947.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ87947.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ87947.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ87947.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ87947.1}.
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DR EMBL; LSYS01001584; OPJ87947.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4KVI8; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12075; SH3_Tks4_1; 1.
DR CDD; cd12076; SH3_Tks4_2; 1.
DR CDD; cd12078; SH3_Tks4_3; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035477; SH3PXD2B_SH3_1.
DR InterPro; IPR035478; SH3PXD2B_SH3_2.
DR InterPro; IPR035479; SH3PXD2B_SH3_3.
DR PANTHER; PTHR15706:SF25; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..128
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 151..210
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 220..279
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 367..426
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 125..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..745
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 91278 MW; B98E919B69FD1721 CRC64;
MPRRSIAEVK VLDVQKRRIP NKHYVYIIKV TWSNGSTEVI YRRYSKFFDL QMQMLDKFPM
EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLIPIDEY CKALIQLPPY ISQCEEVLQF
FETRPDDLTP PKEEPIGKKR SGADSASADP LVLEQYVVVA NYQKQESSEI SLCVGQVVDI
IEKNESGWWF VSTSEEQGWV PATCLEAQDG VQDEFSMQPD EEEKYTVIYP YTARDQDEMN
LDRGAVVEVI QKNLEGWWKI RYQGQEGWAP ASYLKKGNGE MFSQKLGSGS SAHSCALDLD
GISRQQVVVS REKDGLAGQR DGRFDSRPLP NADIRRKSPK MRQRPPPRRD LTIPRGLNLP
KPPVPPQVEE EYYTIADFQT TIPDGISFQA GMKVEVIEKN LSGWWYIQIE EKEGWAPATF
IDKYKKTSNA SRPNFLAPLP NEMAQLRLSD ATADSSTGEE VTGPCRPLPE APPNGTDCGG
KWAKDWKGKE APESGDLALT SGYEEILDRD AEEKPSLPPR KESIIKSEGE LLERQRPPPK
PPGMILPMIP PKQSVAPKDS KKPELKPEKG KLFQLKNEMG LECGHKVSAK EVKKPNLRPI
VKPTKPKAEP VEEKPEPIAQ NPFLKSRPQI RPKPAAAPRT DPPPADDKLD ICSLRSKLRP
AKCPEKPSEN DTTTASESSL ANAMVSSEAS GRFQERPSVE SKPLPKVDSH AMKEALPKSP
LGPANTPGAR EPPPQRPVVP PRRPPPPKKT GDEAKAKGSI SPKVISKPVE RGEAKERTSA
PVPSPDISRD ALYVAVADFE GDEETNSFKE GTLFEKP
//
