ID A0A1V4KVY9_PATFA Unreviewed; 2496 AA.
AC A0A1V4KVY9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=TEX2 {ECO:0000313|EMBL:OPJ88545.1};
GN ORFNames=AV530_003071 {ECO:0000313|EMBL:OPJ88545.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ88545.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ88545.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ88545.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ88545.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ88545.1}.
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DR EMBL; LSYS01001520; OPJ88545.1; -; Genomic_DNA.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR16155; DED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16155:SF3; ZMP:0000000735; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 559..820
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 823..952
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT DOMAIN 949..994
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 404..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2496 AA; 285341 MW; 3318EEF43EB9F7CF CRC64;
MQPRLSSYFI NYKASQNTSS VTVPETLLFV STLDGSLHAV SKRTGAIKWT LKEDPVLQVP
IHVEEPAFLP DPNDGSLYTL GGKNNEGLTK LPFTIPELVQ ASPCRSSDGI LYMGKKQDIW
YVIDLLTGEK QQTLTSSFAE SLCPSASLLY LGRTEYTITM YDTKKKELRW NATYFDYAAS
LPDKDIKYKM SHFVSNGDGL VVTVDSESGD VLWIQNYASP VVAFYIWQRE GLRKVMHTNV
GIETLRYLTF MSGEVGHITK WKYPFPKETE TKSKLTPTLY VGKYSTSLYA SPSMVHEGVT
VVPRGSAIPL LEGPKTEGVT IEDNGECVIT PSTDVKFSGR LKEKNKLSYW NDWLLIGHHE
TPLSAPTKIL EKFPSNLPKR PENVIPADSD KAAIEEVIDI VEGSSTDVPP AAPKDIEEKP
ARPVPRPEAP VDSMLKDMAT IILSTFLLVG WVAFIIAYPM SVHQQQQRQH QLEEKIQLLQ
QQQLPFGAPS DLPPEADFLD PSCGRPENSA ASTPNLSPRA SNHSAYSSVS TSDVGSCIST
EQEEGDEDAN RVMVGKISFN PKDVLGHGAE GTIVYRGTFD NRDVAVKRIL PECFSFADRE
VQLLRESDEH PNVIRYFCTE KDRQFQYIAI ELCAATLQEY VEQKAFSHHG LQPITLLQQT
TSGLAYLHSL SIVHRDLKPH NILISMPNAH GKVKAMISDF GLCKKLAVGR HSFSRRSGVP
GTEGWIAPEM LSEDCKENPT YTVDIFSAGC VFYYVVSDGS HPFGKSLQRQ ANILLGAYSL
ESFSAGRHED IVARDLIEQM INMDPQKRPS ASCVLKHPFF WSLEKQLQFF QDVSDRIEKE
SLDGPIVKQL ERGGREVVKM DWRQHITVPL QTDLRKFRSY KGGSVRDLLR AMRNKKHHYR
ELPPEVQETL GSIPDEFQQH RTFRGFCSLT AGFPSSKAMD YKTLPVDKWD ENHVQCWLQS
TGIKKEYVEK LHAEEVTGPV LMELDEPFLK GIGMKKGQIH MLIRKRNELL QPQENAQPAK
HLNSKTSDRT DPQTDPGIPR NASAQKTSNG DSCGPADKPS GDNTASTSGK RRQSNNTQLQ
STAEVLELSN CRPFRSQNTD FKYVKDRVLA PESGVNGLIT PCHEYKSFAT AAELNKNQLQ
SKFACEVIRF ASACMNIRTN GTIHFGIMDS VEDRGWKHGQ IVGIKVKERE YYVDALDYIE
KCFFKHVQET ARKCIHPPVF VEVISKDSEE QRFVVEVDIE PTSSLVKNKF FQVCLPKYNE
DKKRVDLTET SVPYQRLGAK SEPVKHNDLA TFLQGLQDRD AEREKAELSS AEVHTEIPQN
LGRKLSILLN DGKSYMDDSL RYILVTNRCE KNDLNYINFL MHLNIFCVFD FDEDSNVSGL
CSKYKEHHAV RLYFLQDFSN ESKTGNPPAQ KHLCLFDQTS WIFCNGRSDF LGNEEPCDEN
TWIRTKKKYL KKAITRICDE ILPKRSFIVL FLLLSPVQKP LVDTFQEFYT EMNGMEYIVC
IAESRENYNK WANLAQTSCS IETLEQCSVV GMKLSHVDAT IETMLPSTAQ PRHLPVSSRG
LCTLPSREEE KLFSLEILCV DQCNDIKLDC LTEKEIQEME QNFYRGRKII WENFWLADTR
RCGEIIEREA CKDASKLLDD ILQGSGLNYS VAKLKIFHHP GSGGSTIARQ VLWKRRKDLR
CAVIKTSYPP ATVCEHALAF RDYEEKEFSH CLPVLLLIED YDEDYLEELR NELMDAVSTR
KINSPRPYFI LMCCRRSNDP ERLCKASPLD TVAVTHKLTD TEKSLFKTKL EKLKQKDVKP
EFILTFVLMC EEFNETYVRD FVGHILQGID RSSRDTLLMR YVALLSFYVP HSYVSLSHCE
AFLGLGVYTE SRSRAYDFKS HLSEQARMIF IELRDSTTYI SSVRIIHYLV AKEILHQLSG
DEPQSQLAMT LLQEKTLFEN RFGREEFIKF IRDLFIRRDK RSRGDNTDTL FSPFIEHVCK
VEDCEKAIHV LKAAYELLGK DPFFAQQLAR LHYSNEKFED AEHWARIAKF HLPNDSYILD
TEGQVYRKWF SFMVDKRTQE DSPEHIIQRI EMALKAMKCF RAAQQAAKAE RDSMNNAGYF
GEVEVGCRLL RFLSTVHVFR RSPEGEHSEL VKYLITDYVP KDIEKTWGCF HSCLKGLRQN
LYNALEWISE DLSYFQTDKH HQREEEDEKD EKEEQIYNPR KWLKRQSEVY AKFFVSASLL
EESNSGPESQ LIRRMNIYKN GGGSVTNILS FLTDKKESRS ADKLENILSF YTENPLRDRL
EDNDLINYIL CHITLACLSP GSAKLLPAQT LRDLSARFFK GKRPFPASAY FLLTLLYWPD
EALDKEPNPD KDEILNSALQ TLKRLYDIKM KDVPTRKKRI YTHFFLGKGY GLSKIVHKTK
IDKLITGSLD EKRMKWLHGT VWNIAKIRDI LKRVSGWTKD RNLFIRGHVK EFPILPLHRD
SVPPGNENVT FYLGFSFNGL VAFNIEVENN PTVSRT
//
