ID A0A1V4L1C8_PATFA Unreviewed; 2110 AA.
AC A0A1V4L1C8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis protein 8 isoform B {ECO:0000313|EMBL:OPJ90436.1};
GN Name=DOCK8 {ECO:0000313|EMBL:OPJ90436.1};
GN ORFNames=AV530_008628 {ECO:0000313|EMBL:OPJ90436.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ90436.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ90436.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ90436.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ90436.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ90436.1}.
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DR EMBL; LSYS01000242; OPJ90436.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4L1C8; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11701; DHR2_DOCK8; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF74; DEDICATOR OF CYTOKINESIS PROTEIN 8; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 567..736
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1643..2077
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
SQ SEQUENCE 2110 AA; 239857 MW; F78C50627600295C CRC64;
MATLPAADRR AFALKINRHS SAEIRKQFTL QPGFAQFCQR SLSTPGISAL HLPIILKKPS
FYDAVDPVDF EGFLMTRLNN LDSELAQELG DFPEDDLDVV FTPKECRTLQ PSMPEDGAEL
DSHVRDCVQT YVREWLIVNR KNQGNSDTCS LKNKGSRKDF HKMLQKQTFE SETLDSSDAN
FQAGPRHVQA LPEEPSRTTL TSSDFDLRSL QPDPRLENLL RHLSPEEFER QNEEARRTNR
HAELLALYPA VDEEDAVEIR PVPDRPKEHL GNRILVKLQT LKFDIEIEPL FACIALYDIK
ERKKISENFH CDLNPDSLRG FLRSHTPSID LSTQARSAVF SVTYPSSDIY LVLKIEKVLQ
QGEIGDCAEP YMVLKESETG KTKEKIEKLK AQAESFCQRL GKYRMPFAWI PVALTNFFNL
STLEREIPEA EGLNGKGSTS DKRATLLQAR RFSERSLSSE DSYPVSNFKT TSLTLNTFFK
QEGDRLSDED LFKFLADFKR SSSLQRRIKT LPGTLKLEIS AAPESLGYCL TPELLPVKPF
PENRNRPHKE ILEFPIREVY VPHTIYRNLL YVYPQRLNFA NRPGSARNIT IKIQFMCGED
PSCAMPVIFG KSSGPEFVQE IYTAITYHNK SPDFYEEVKI KLPAKLTEKH HLLFTFYHIS
CQPKQGASVE TLLGYSWLQI LLNDRLQTGH YCLPVALDKL PFHYSIHSPE KVPSQTPPVK
WVEGHKGVFN VAVQAVSSVH TQDNHLEKFF TLCHCLESQV TFPIRLMDQK ITEAALEHEL
KLSIICLNSS RLEPLVLFLH LVLDKLFQLA VQPMVIAGQT ANFSQFAFES VVAIVNSLHN
SKDLSKDLHG RNCLLASYVY YVFRLPDPQR EVVKPGAASS AISTESRYYT FGRTSAASVG
SKLLQSRVIS CSNPDITVTQ TATDEEVKNI MSSKPMDHSS SRMSFYVEGT NDMPSVCANS
RPSNKKHFHE ELALQMVVST GMVRETVFKY AWFFFELLIK SMAQYVHNIE KQDNPRRSRF
SDRFKDDITT IVSVVTSEIA ALLVKQKESE QAEKINISLA FFLYDLLSLM DRGFVFNLIK
HYCNQLSNKL NSLSTLISMR LEFLRILCSH EHYLNLNLFF MTSASAPASP SPSLSSQNSS
SCSSFQDQKI AGMFDLSAEY RQQHFLTGLL FTELAAALDA DGEGISKVQR KAVSAILSLL
SSHDLDPRCS KKEVKIKIAA LYLPLVGIIL DSLPQLHDFT IADARSGKGR TGNPEEEQES
PGAINQNVAL AIAGNQFNLR SSGISLVSMP YRQSATLGPD TTRNLLICFL WIMKNADQNL
IQKWIADLPS MQLNRILDLL FICVSCFEYK GKQSSDKVST QALQKSRDVK ARLEEALLRG
EGARGEMMKR CRIPAGNDRS VGLNENLRWR KEQTHWRQAN ERQDKSKAEL DQEALVSGNL
ATEANLIILD MQENIIQASF AAECRDNLLG GVLKVLVNSL GCDQSTTYLT HCFATLRALI
AKFGDFLFEE EVEQCADLCQ RVLHHCSSSI DTTRTQACAT LYFLMRYSFS STSNFARVKM
QVTMSLASLV GKSPEFNEEF LRRSLRTILA YAEEDADMQA TPFPIQVEEL LCNLNSILSD
TVKMREFQED PEMLMDLMYR IAKGYQTSPD LRLTWLQNMA EKHTKRKCYT EAAMCLVHAA
ALVAEYLSML EDRNYLPVGS VSFQNISSNV LEESAVSDDV LSPDEDGICS GRYFSESGLV
GLLEQAAELF STGGLYETVN EVYKIVIPIL EAHRDFRKLT LTHSKLQKAF DSVINKGQKR
MFGTYFRVGF YGSKFGDLDE QEFVYKEPAI TKLPEISHRL EGFYGQCFGE DAVEVIKDSA
PVDKRKLDPN KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LCRFMYTTPF TMDGRPRGDL
SEQYKRNTIL TTMHAFPYIK TRINVIQKEE FILTPIEVAI EDMQKKTQEL TAAINQEPPD
AKMLQMVLQG SVGATVNQGP LEVAQVFLSE IPADPKLYRH HNKLRLCFKE FIMRCGEAVE
KNKRLITADQ REYQQELRKN YGKLKENLRP MIERKIPELY KPVVKVHSTR ESFRNHSFRK
YDAQTSSQST
//
