ID A0A1V4M8X5_9FIRM Unreviewed; 890 AA.
AC A0A1V4M8X5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|PROSITE:PS51371};
GN ORFNames=AVO34_03210 {ECO:0000313|EMBL:OPL11115.1};
OS Firmicutes bacterium ML8_F2.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1775675 {ECO:0000313|EMBL:OPL11115.1, ECO:0000313|Proteomes:UP000189969};
RN [1] {ECO:0000313|EMBL:OPL11115.1, ECO:0000313|Proteomes:UP000189969}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ML8_F2 {ECO:0000313|EMBL:OPL11115.1};
RA Hamilton T.L., Pearson A., Macalady J.;
RT "Carbon and sulfur cycling below the chemocline in a meromictic lake.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPL11115.1}.
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DR EMBL; LQBG01000067; OPL11115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4M8X5; -.
DR Proteomes; UP000189969; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd04595; CBS_pair_DHH_polyA_Pol_assoc; 1.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR PANTHER; PTHR47788:SF1; A-ADDING TRNA NUCLEOTIDYLTRANSFERASE; 1.
DR PANTHER; PTHR47788; POLYA POLYMERASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 312..370
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 374..434
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 890 AA; 101557 MW; CE68D9C063881C69 CRC64;
MDLIITHENS DFDALAAVVA AAKLYPGSYV LLPEQLQPNV RSFVNLHRDL LPLIDPREIV
DDNIDLLLII DTNRRERLGK WEYMVDRAAH VYIYDHHPGD EDIDAEKSSI EAIGATTTIL
LEKLRKKKIK ITEFEATLFA LGIYEDTGCL TYEITTSRDA RAVSYLWDAD LSVSLLQEYL
RSPLNDTQKR LLEKLIHSSE LHELNRRRVL ISSTSLNEYV VGASVLLQLL DEIEDAGMTI
VIIRMTDSIY MAARSRDEDL NLLELLAPFD VRGYPAAVST HFKGTNTEVV KEQVLAYLEE
NLPFSLTAGE VASRPVFSLD SDTSLDVADG LLVEHNFKGC PVMEKGRLVG IISRRDLQKG
MRNELGHAPV KGFMTRQVIT ASPQDSLTEL RRLMMEHNIG RVPIVDEMDK LGGIITRSDI
LRHLNYFDRH GHSLKKRSSI DGSYERVDGE EKLTGGDELN LLELVESGLS TEIKSLLRTI
SRLAERKNME VYMVGGIIRD LLLRYPPEKD LDFVVIGDAI AFTYALQKIS NGTVRHFDQF
GTASLYMKDG TRLDFVTARR EYYESPAALP RVESSGLKND LFRRDFTINA MACSLDSENY
GRLYDYFNGR KDLRNRLIRV LYELSFVDDP LRILRAVRFE QRYNFTIDEE TLKLIEKAID
KKVLVKVSRQ RINHELRIVF REPSPVRILK RFEQLGLIDL LYPGAKTDSE TWLRLSSLEK
LLRRAEEKGW QNKPDREMVY LSSLLYGLES AKRSAIIKKL NLSREKADAV KVACLEAPSV
VEKLADEEHK PSTIVSLLQH LPAETIFLAY TLAGLKTIRS RLKLYLDQLQ LVKPHLNGSD
LKRIGLKPGP FYRRVMADLQ KAVLDGELKT EEEEVAFVEK YMKEMKTGED
//
