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Database: UniProt
Entry: A0A1V4SDG0_CLOHU
LinkDB: A0A1V4SDG0_CLOHU
Original site: A0A1V4SDG0_CLOHU 
ID   A0A1V4SDG0_CLOHU        Unreviewed;       440 AA.
AC   A0A1V4SDG0;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   13-FEB-2019, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA_1 {ECO:0000313|EMBL:OPX41952.1};
GN   Synonyms=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CLHUN_41750 {ECO:0000313|EMBL:OPX41952.1};
OS   Clostridium hungatei.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Hungateiclostridiaceae; Ruminiclostridium.
OX   NCBI_TaxID=48256 {ECO:0000313|EMBL:OPX41952.1, ECO:0000313|Proteomes:UP000191554};
RN   [1] {ECO:0000313|EMBL:OPX41952.1, ECO:0000313|Proteomes:UP000191554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14427 {ECO:0000313|EMBL:OPX41952.1,
RC   ECO:0000313|Proteomes:UP000191554};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Clostridium hungatei DSM 14427.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OPX41952.1}.
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DR   EMBL; MZGX01000039; OPX41952.1; -; Genomic_DNA.
DR   BioCyc; GCF_002051585:CLHUN_RS20835-MONOMER; -.
DR   Proteomes; UP000191554; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000191554};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191554}.
FT   DOMAIN      135    263       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      347    416       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   440 AA;  50096 MW;  DA95F522DBEE7B30 CRC64;
     MNVQLNDIWN RTLELLKGEM TEISFNTWIL TIEPVNIDSS TITLGVPADF QKGILESRYS
     YLIKNALRQI THKDYNIFFS TPSQTPVKPA VQEYSEDTSG LLLNPKYTFD TFVIGNGNRF
     AHAASLAVSE APAKAYNPLF LYGGVGLGKT HLMHAIGHFV LNQNPALKVL YVSSEKFTNE
     LINAIKDDKN EEFRYKYRNI DVLLIDDIQF IGGKERTQEE FFHTFNALYE ANKQIIISSD
     KPPKDITTLE ERLRSRFEWG LIADIAPPDL ETRIAILRKK AQLENLDVPD DVMVFIADKV
     ASNIRELEGA MNRVIAYSTL TENKINVDMA LEALKDMFNN SKAAVINSKT IQEAVARYFH
     LKTDELKSKR RSRDVSFPRQ IAMYLCRDMT EMSLPKIGDE FGGRDHTTVI HACEKISHDM
     DNSSELRRTI EDIKKNVVGN
//
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