ID   A0A1V6LPF4_9FLAO        Unreviewed;       588 AA.
AC   A0A1V6LPF4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:OQD41856.1};
GN   ORFNames=BUL40_13445 {ECO:0000313|EMBL:OQD41856.1};
OS   Croceivirga radicis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Croceivirga.
OX   NCBI_TaxID=1929488 {ECO:0000313|EMBL:OQD41856.1, ECO:0000313|Proteomes:UP000191680};
RN   [1] {ECO:0000313|EMBL:OQD41856.1, ECO:0000313|Proteomes:UP000191680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HSG9 {ECO:0000313|EMBL:OQD41856.1,
RC   ECO:0000313|Proteomes:UP000191680};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQD41856.1}.
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DR   EMBL; MTBC01000010; OQD41856.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6LPF4; -.
DR   OrthoDB; 9780502at2; -.
DR   Proteomes; UP000191680; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd00361; arom_aa_hydroxylase; 1.
DR   Gene3D; 1.20.58.690; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:OQD41856.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191680}.
FT   DOMAIN          1..343
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         132
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         137
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         222
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   588 AA;  65878 MW;  B5DDCF8A5FBD1EFB CRC64;
     MKEQLYESNP VLDKLPEHLR QYIKPQNYEE YTPVDQAVWR YVMRKNVDYL SKVAHKSYVD
     GLQKTGISID AIPNMYGMNR ILKEIGWAAV AVDGFIPPSA FMEFQAYNVL VIASDIRQLE
     NIEYTPAPDI IHEGAGHAPI IANPEYSEYL RRFGEIGAKA ISSGKDYELY DAVRHLSIIK
     EAEGTPLEAI EKAEKRIEAL QQNMGKPSEM ALLRNLHWWT VEYGLIGTLE NPKIYGAGLL
     SSIGESAWCM TDNVKKLPYT LNSATTDFDI TKPQPQLFVT PNFAHLSQVL EDFANTMALR
     TGGLSAVQKL IDSQALGTLE LSTGLQVSGY FERVLSHDGL PIYFTTKGAT ALAYHDKELV
     NHGTTQHPEG FGSPVGKLKG INLAIEDMSP RDLKAYNIFE GEKVELEFVG GVTVSGEIIT
     GTRNLQGKII LITFQNCTVT YQDEVLFKPD WGLYHMAVGR KVSSGYNGPA DLKSFNLVSH
     ALSDTTVKKN RDDNKLALEE FYQRVRDYRE GKNTIISRGK LFQEFISRFP KDWLLPVELY
     ELAVKGNRTV LATEIKAHLE QLKLDRPKVG HLIDDGLALV DQGLKIDA
//