ID A0A1V6MN48_9ACTN Unreviewed; 2622 AA.
AC A0A1V6MN48;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=BM536_026515 {ECO:0000313|EMBL:OQD53808.1};
OS Streptomyces phaeoluteigriseus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=114686 {ECO:0000313|EMBL:OQD53808.1, ECO:0000313|Proteomes:UP000184286};
RN [1] {ECO:0000313|Proteomes:UP000184286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41896 {ECO:0000313|Proteomes:UP000184286};
RA Schniete J.K., Salih T., Algora Gallardo L., Martinez Fernandez S.,
RA Herron P.R.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OQD53808.1, ECO:0000313|Proteomes:UP000184286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41896 {ECO:0000313|EMBL:OQD53808.1,
RC ECO:0000313|Proteomes:UP000184286};
RA Salih T.S., Algora Gallardo L., Melo Santos T., Filgueira Martinez S.,
RA Herron P.R.;
RT "Draft genome sequence of Streptomyces phaeoluteigriseus type strain
RT DSM41896.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD53808.1}.
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DR EMBL; MPOH02000016; OQD53808.1; -; Genomic_DNA.
DR STRING; 114686.BM536_026515; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000184286; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 991..1066
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2047..2121
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2622 AA; 279678 MW; 8CFDA60165F81776 CRC64;
MSESFSHELP LSLAQREMWY AQQLDPGNPV FTMADHLDLH GPLDPARFAA AWHGLLAETD
ALRAVFTERD GEAVQTIREF TWEVREGTLD RADPADPASP LTTPGVAVRD LRAEADPDAV
SRRLMAEDLA LPSSLTDGAV RWQLHRLADD HHRFYVSANH ILLDGFSRTP FYRRFAELYA
GTADGEPLPP LRVLVDDEQA CLHSAKHERD ARFWAGRFAE TPEPTRLSPR RPLRARHTLR
WNSPVPAATV TRLERAAWES RVTLPAALVA ATASYLARVT GGSRVLLTLP VPARTTPTAR
TVPGMRANFL PLPLDVTPAL TRDGLLELTA AELRTTLRHQ GYRGDRLRRE LGLAGDAELS
YGPTVNVLES GADLVFGECT GRLHNLSTGP VPGLQLIYLD APGGRWTLRL DANPGLFTDE
ELAAHGERLL GHLESFALAP AALPLGRLDV TLPAERQVVL EDWNATVRTG GFTDVVERVR
ELAAASPDAI AVDDGTVRLT YADLCARADE VSLRLAGAGV ATGSLVALAA DPGTQFVAAV
LGVLATGAAW IPLDVHAPVA RGAALLADSG AEALLFSPVR EGYAHQLLAA GDHWPKIVEL
LDVREGGKRA DAPTAAAPAA GTGDDLAYVI FTSGSTGRPK GAMVHRAGMV NHLLAKVEDL
GLTPDDVLVH NAPVSFDISV WQMLAALVAG GRTRVVPRSL AADPQGLFAL VDEEDITVLE
VVPSLLRAAV DDWDSGAARP RLASLRHLVV TGEALPADLC RRWFAHFPGV PLVNAYGPTE
ASDDVTHAFI RSEADLGDVH TPIGSAIRNT RLYVLGDGLR PVPVGAPGEL YVGGVGVGRG
YLDDPRRTSA VFVADPFATE PGARMYRTGD RVRHRTDGRL EFLERVDHQV KIRGHRIELG
EVEAALRGVT GVTDAAVDVA VDSAGSTRLA AFVTGDVDVA EVKAELSTTL PDYMVPAAFV
VLDRLPLTAN GKVDRKALPA PDLTAGQPGR RPRTPREQVL CAVFAEVLGV EQVGIDDDFF
EFGGHSLLAT RAISRIRVLL GAELPVRVLF EAPTVAALAE HLTEAGAARP AVTAQERPAA
LPLSFAQQRL WFLDRLDADA AVGYHLPRAV RLTGPLDHEA LAAALGDVVD RHESLRTVFP
ERDGRAVQVV LPARNGPFDL PVTEVAAGDL DAVLAERAVR PFDLAADLPL RAELCTLSDQ
EHVLLVVLHH IAGDGWSVLP LAEDLRTAYT ARTAGHAPGW APLDVQYADY TLWQRELLGD
SADPGSLAAR QLDFWRGELT GIPDELELPT DFPRPALPAH RGGQISFRLD RELHEAVTAL
ARATGASVFM VLQAALAAML RKLGAGTDIP LGTPVAGRTD AALERQVGFF VNTLVLRTDV
SGDPTFRELI GRARTTDLAA YAHQDVPFEW LVEALNPERS LARQPLFQVL LALQNNAATD
LALPGTRAET TAVPTGTARF DLAFELTEEQ DGRGRPDGIA GLLEYSADLF THESAESVAA
RLVSLLHALT ERPDTALSGF DALLPAERER LFGEWNGSAV EAPEPTTIAR LFAARAATDP
HRPALALPDG TTVSYGDLAD RAHRLAHLLV ERGVRPGQVV ALMADRSAHT VTAVLAVLAA
GAAYLPIDPA YPDERIAYVL DDARPAAVLT TAAVADRVPA TAPEPLVLDA DTVLADLTGR
PTRAPEHGPA PGDPAYVIYT SGSTGRPKGV VVGHASATAL TAQAARFGVR EGTRLLQFAS
LSFDAAAWEV LTALVTGAVL VLATEDQRAP GDPLAAHLTD AGIDVVCLPP AVLAAWPEDR
PVPSGITVIT AGEACPPALV EKWAAHTTLL NAYGPTETTV CATVSDPLVP GRRPSIGTPL
AGTVVHVLDD DLRPVPAGVT GELYVGGASL AHGYLGRPDL TAQRFVTDPY GPSGARMYRT
GDLVRRRADG VLDYLGRADD QVKLRGFRIE LAEVEAALAA HPEVDRAAVV VREDRPGDKR
LVAYVVPAAG TTAPPATLRS HVAGLLPDYM VPAAVVTLAG LPLTTNGKLD RRALPAPDYT
DATRGRAPVT ERERALCAVF GEVLGLDEVG ADAGFFDLGG DSISSIQLVG RARAAGLLLT
AQDVFLHRTP AGLAAVARPV DEQVVRGTDD GIGTFPPTPI MRWLHALDGP CDAFRQAVAV
RTPAGATRAS LATALQTLID HHDALRTQLL DEDGTWTAKV REPGTVNAPW LLVRENVARL
DGPALAQAVR DAASADAARL DPRQGTMLRA TWLDAGADRP GRLVLTLHHL VCDGVSWRIL
LDDLARAHEA AVAGGPAELE PVGTSVRHWA RLLVAEAASE QRAAEGELWR RTLAAPDPLL
GGRPLDPARD THATARTLRR TLDTEATRAV LTEVPAAFHA EINDVLVTAY ALAVADWRRR
TRDDAAAVLI EMEGHGREEI ADGIDLGRTV GWFTTTYPLR VDLGAPDWAE VWAGGPSAGR
VLKQVKEQLR AVPDHGVGFG VLRRIAALPG LERTPQLGFN YLGRLPAPRD ADWATTEESP
LIAAGADPGL ALPHTLGLNA LTEDGPDGPR LTAVWTWPGE LLDEADAADV AEGWFRALRA
LVAHAQNPDA GGHTPSDVDL IALSQDELDA FENEMDDWGA SL
//
