ID A0A1V6MQP3_9ACTN Unreviewed; 1179 AA.
AC A0A1V6MQP3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BM536_022570 {ECO:0000313|EMBL:OQD54695.1};
OS Streptomyces phaeoluteigriseus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=114686 {ECO:0000313|EMBL:OQD54695.1, ECO:0000313|Proteomes:UP000184286};
RN [1] {ECO:0000313|Proteomes:UP000184286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41896 {ECO:0000313|Proteomes:UP000184286};
RA Schniete J.K., Salih T., Algora Gallardo L., Martinez Fernandez S.,
RA Herron P.R.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OQD54695.1, ECO:0000313|Proteomes:UP000184286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41896 {ECO:0000313|EMBL:OQD54695.1,
RC ECO:0000313|Proteomes:UP000184286};
RA Salih T.S., Algora Gallardo L., Melo Santos T., Filgueira Martinez S.,
RA Herron P.R.;
RT "Draft genome sequence of Streptomyces phaeoluteigriseus type strain
RT DSM41896.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD54695.1}.
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DR EMBL; MPOH02000015; OQD54695.1; -; Genomic_DNA.
DR RefSeq; WP_073493552.1; NZ_MPOH02000015.1.
DR AlphaFoldDB; A0A1V6MQP3; -.
DR STRING; 114686.BM536_022570; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000184286; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 79..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 130701 MW; 4838E14E04A77DBD CRC64;
MSKPPFTHLH VHTQYSLLDG AARLKDMFDA CNEMGMTHIA MSDHGNLHGA YDFFHSAKKA
GVTPIIGIEA YVAPESRRNK RKIQWGQPHQ KRDDVSGSGG YTHKTIWATN ATGLHNLFKL
SSDAYAEGWL QKWPRMDKET ISQWSEGLVA STGCPSGELQ TRLRLGQYDE ALKAAADYQD
IFGKDRYFLE LMDHGIEIER RVRDGLLDIG KKLGIPPLVT NDSHYTYAHE ATAHDALLCI
QTGKNLSDPD RFRFDGTGYY LKSTDEMYAI DSSEAWQEGC ANTLLVAEMV DTTGMFEAKN
LMPKFDIPEG YTEVSWFKEE VRRGMERRFP GGIPEDRQKQ VEYEMDVIIQ MGFPGYFLVV
ADFIMWAKNN GIAVGPGRGS AAGSIVAYAM GITDLDPIPH GLIFERFLNP ERVSMPDVDI
DFDERRRVEV IRYVTEKYGA DKVAMIGTYG KIKAKNAIKD SARVLGYPYA MGDRLTKAMP
ADVLGKGIDL NGITDPSHPR YGEAGEIRAM YENEPDVKKV IDTAKGVEGL VRQMGVHAAG
VIMSSEPIVD HAPVWVRHTD GVTITQWDYP QCESLGLLKM DFLGLRNLTI MDDAIKMVKA
NKGIDLEMLA LPLDDPKTFE LLCRGDTLGV FQFDGGPMRS LLRQMQPDNF EDISAVSALY
RPGPMGMNSH INYAERKNGR QEITPIHKEL EEPLQEVLAV TYGLIVYQEQ VQKAAQIIAG
YSLGEADILR RVMGKKKPDE LAKNFTIFQA GAKKNGYSDE AIQALWDVLV PFAGYAFNKA
HSAAYGLVSY WTAYLKANYP AEYMAALLTS VKDDKDKSAV YLNECRRMGI RVLPPNVNES
ESNFAAQGDD VILFGLSAVR NVGTNVVESI IKSRKAKGKY SSFPDYLDKV EAVVCNKRTT
ESLIKAGAFD SMGHTRKGLT AQYEPMIDNV VAVKRKEAEG QFDLFGGMGE EQNDEPGFGL
DVEFTTDEWD KTYLLAQERE MLGLYVSDHP LFGLEHVLSD KADAGIAQLT GGEHADGAVV
TIGGIISGLQ RKMTKQGNAW AIATVEDLAG SIECMFFPAT YQLVSTQLVE DAVVFVKGRL
DKREDVPRLV AMELQVPDLS NAGTNAPVIL TIPAVKVTPP MINRLGEILT HHRGDSEVRI
KLQGPTKTTV LRLDRHRVKP DPALFGDLKV LLGPSCLAG
//
