ID A0A1V6P7S7_PENDC Unreviewed; 1029 AA.
AC A0A1V6P7S7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 03-MAY-2023, entry version 27.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
GN ORFNames=PENDEC_c019G06208 {ECO:0000313|EMBL:OQD72802.1};
OS Penicillium decumbens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=69771 {ECO:0000313|EMBL:OQD72802.1, ECO:0000313|Proteomes:UP000191522};
RN [1] {ECO:0000313|Proteomes:UP000191522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 11843 {ECO:0000313|Proteomes:UP000191522};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD72802.1}.
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DR EMBL; MDYL01000019; OQD72802.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6P7S7; -.
DR STRING; 69771.A0A1V6P7S7; -.
DR OMA; HEMFLFG; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000191522; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000191522};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 104..269
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 344..1027
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 1029 AA; 114933 MW; 2C36448D23878E6F CRC64;
MEEQVASAIE IAWNPSSDHA LRSQALEYLN QLRSDPSGWQ VCLALFTKTP RQPEHVRHVS
LEVVNNAAQA GLIDLVSLGV VRNELMGYLR QVYGPDGVAT PDAPYIQNKI AQTVTLLFSA
LYGNGWETCI DELLSLTYKS AASTTRDNAL GIVFYLRVVN SIHEEIGDVL VSRSRGEQDK
ANSLKDLIRA RDMQKIASSW QEILSEWRDG DDTVVQMCLK AVGSWVSWID IGLVVNQTML
DLLFQQLGRA EKQELREGEQ RVRDAAVDVF TEIIGKKMRP AEKIEMIIFL NLDSIVTQLS
NSPPLREARF TFKYDTDLAE TVAKLVNITV MDIVRVLETD NGPVKEKADD LLQVFLPHIL
RFFSDEYDEV CSTVIPGVND MLTYLRKLAK SNPAFEERNK TILLPILKAV VAKMRYDETS
NWGDEDEQTD EAEFQELRKR LGVLQQTIAS ADEQLYIDAI SEIVGTTFEN LRASGGQIDW
RDLDLALHEM FLFGDLAVKS GGLYQKNQPT GPPAVRLIEM MLRMVESDIR SFTHPATQLQ
YMEICVRYSS FFQHHQHLIP GVLESFLQLV HHPVLKVRTR SWYLFQRLVK QLRAMIGNVA
QTVVEALSDL LVIKAELPSE GEDGDEMSSE DHEGFADAVF NSQLYLFEAV GIICSTNGVP
ADKQVLYAQS VLNPIFADME RNLAAAKAND ERALLQIHHD IMALGTLARG FSDWMPGTST
PASLPAPEVS EAFCQVAEAT LVALESLKAS FNIRTAARSA FSRLIGVLGA RILPQLPRWI
DGLLTQTSSR DEMALFLRLL DQVIFGFKAE IYSILDTLLT PFLQRVFSGI ADPTTGTDDE
IQLAELKREY LNFLLAVLNN DLGAVIISER NQLIFETVIS TIEHFAKDID DFTTAKMAFL
VLSKMGSSWG GPDIAPVNGA ATTTAQTQLP GFGGFMITRF SPLCWALPTT PSFNSKDPQA
KQVLVEAGAL QRTIYSKTGM EYADYLRTQE LPGMGMGAEL IEEYLTALSQ LDMKGFRQFF
PSFIQRLSA
//
