ID A0A1V6PC69_PENDC Unreviewed; 1008 AA.
AC A0A1V6PC69;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENDEC_c011G06136 {ECO:0000313|EMBL:OQD74327.1};
OS Penicillium decumbens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=69771 {ECO:0000313|EMBL:OQD74327.1, ECO:0000313|Proteomes:UP000191522};
RN [1] {ECO:0000313|Proteomes:UP000191522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 11843 {ECO:0000313|Proteomes:UP000191522};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD74327.1}.
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DR EMBL; MDYL01000011; OQD74327.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6PC69; -.
DR STRING; 69771.A0A1V6PC69; -.
DR OMA; GDMYCSL; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000191522; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14475; SPX_SYG1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191522};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..434
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 684..878
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 32..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..978
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 115713 MW; C5D3B18BD82E7E82 CRC64;
MKFAKELEQE LVPEWRAKYL DYKGGKKKLK ALSRALRQAH RSPRTPSFRQ TPFSHATTLT
PSNADKQLDA GEIDKATPQQ TGATTSSYGR STPAQKAERQ PLQTPRSRFS RNIGSYGSIH
ATPPQRHRQG SDAASFELPD PALDPDEEYM PPQGQQGHQE GQAVRTPSPV ATRHATFRDL
PEHAVTDGSP EQASLARHPT AQSPQGKALT KSTSVNRTSQ LMRRVFSYPD VDTIGKGSQA
HSESDFEKQE KAFFKYLDEQ LEKIDTFYQM KEQEAAERLK VLRRQLHIMR DQRIHEFYAA
KRANKRRAVD TQDTPQAFGK LNSSRLKDTL TGKVHFGKNS QALAEMATPK IPTRDRKFAS
NRRDFMRRQE PPNNDVYDVS YRSAKRKLKH ALQEFYRGIE LLKGYAYLNR TAFRKINKKY
DKVVNAPQPQ RYMSEKVNKA SFVESDVLET LMSAVEDLYA RYFERGDRKI AASKLRHTLK
KPGDYSPSTF RSGLLLMAGT LFGIQALVYA TQHLRSAEVR QHVWTSYLLQ IYGGYFLIVF
HVLLFSLDCM VWTKSKINYE FVFEYDSRHT LEWRQLLEIP SFFIFLLGLF MWLNFSWINA
MYIYWPVVLI GLTLIIIFLP ARVLYHRSRK WWAFSNWRLL LAGIYPVEFR DFFLGDMYCS
QVYAMGNIEL FFCLYAYHWS NPVKCNSSHS RLLGFFTTLP AIWRAFQCIR RYIDTRNAFP
HLLNLGKYIF TILYYATLSM YRIDRHTRFQ AAFITFGLLN AVYTSVWDLI MDWSLGNPYA
KHKLLREVLT FHRTWVYYVA MVVNVVIRFN WIFYAIFVND LQHSAVLSFI ISLSEVVRRG
MWSIFRVENE HCTNVLLFRA SRDVPLPYDA PAPATSTPGL DGTQPEDVQL QEQQPATPFM
ASADVETGAH SISSLRARKR APSFAKAVGN AMSAAHAQDF QRRRVPAQIS GATVSQDMGH
GAEESSDEDG DDNGALDTDE DSGSTVEISY EGSQAASDRR LQIGRIVE
//
