ID A0A1V6PCZ7_PENDC Unreviewed; 861 AA.
AC A0A1V6PCZ7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=PENDEC_c009G00407 {ECO:0000313|EMBL:OQD74950.1};
OS Penicillium decumbens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=69771 {ECO:0000313|EMBL:OQD74950.1, ECO:0000313|Proteomes:UP000191522};
RN [1] {ECO:0000313|Proteomes:UP000191522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 11843 {ECO:0000313|Proteomes:UP000191522};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD74950.1}.
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DR EMBL; MDYL01000009; OQD74950.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6PCZ7; -.
DR STRING; 69771.A0A1V6PCZ7; -.
DR OMA; FLKINMT; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000191522; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000191522};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 393..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 601..661
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 713..772
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 94784 MW; B17CD8B2F53E024D CRC64;
MTSNRPFPTL RSPSILNERR DFRRLSGRSV SSPVDPEPAP DVQPTAITEE ISEIKRYEDF
TTIDWVQDAV YEQSARRAKR RGGGGFWDQE GVFGWRRKMR ESYDAGQAWL VVTIVGMAIG
LNSALLNIIT EWLSDIKLGH CTTAFYLNEQ FCCWGAEGGC PEWKHWTGFW PVNYVVYFIF
AMLLAFVAAI LVKSFAPYAA GSGISEIKCI IAGFVMKGFL GAWTLLIKSI ALPLAIASGL
SVGKEGPSVH FAVCTGNVIS RFFGKYKQSA SKTREILTAS AAAGVAVAFG SPIGGVLFSL
EEMANYFPLK TLWRSYFCAL VATSVLAALN PFRTGQLVMF QVEYDRTWHF FELIFFAFLG
VFGGLYGAFV IKWNLRMAAF RKKYLSQWPI TESVVLAALT AVLCYPNMFL RINMTEMMEI
LFRECEGGHD YDGLCETKNR WSMVLSLAIA TILRTGLVII SYGCKVPAGI FVPSMAIGAS
FGRMVGIMVQ ALHESFPDAA FFASCEPDVP CITPGTYAFL GAGAALSGIM HLTISVTVIM
FELTGALTYI LPTMIVVGVT KAVGDRFGNG GIADRMIWFN GFPFLDNKED HVFNVPVSHA
MTTDPLTLPA SGFPVREAEH LLSDNKFQGF PIVEDRNSKT LVGYIGRTEL RYAIDRSRSD
GLVSPRARCV FTKEAAETAV ARRASVSQSR LTDTFEGIES SVGAAVVDFS RYVDHTPLTV
HPRLPLETVM EIFKKMGPRV ILVEHRGRLT GLVTVKDCLK YQFKVEAEEH ALAATSSSGF
ASAPLGGHLT SPAPETLEDR LWRIIQTVAG FVSGKIGPNR SVPLQDRRRA SPSRASGILD
GTEDDGFVEL EEREERLGGR S
//
