ID   A0A1V6PEV7_9EURO        Unreviewed;      1436 AA.
AC   A0A1V6PEV7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN   ORFNames=PENANT_c153G09885 {ECO:0000313|EMBL:OQD75548.1};
OS   Penicillium antarcticum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD75548.1, ECO:0000313|Proteomes:UP000191672};
RN   [1] {ECO:0000313|Proteomes:UP000191672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQD75548.1}.
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DR   EMBL; MDYN01000153; OQD75548.1; -; Genomic_DNA.
DR   STRING; 416450.A0A1V6PEV7; -.
DR   OrthoDB; 614488at2759; -.
DR   Proteomes; UP000191672; Unassembled WGS sequence.
DR   GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07216; Pat17_PNPLA8_PNPLA9_like3; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002151; Kinesin_light.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   NCBIfam; NF040586; FxSxx_TPR; 1.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   Pfam; PF13374; TPR_10; 3.
DR   Pfam; PF13424; TPR_12; 6.
DR   PRINTS; PR00381; KINESINLIGHT.
DR   SMART; SM00028; TPR; 14.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          23..223
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   1436 AA;  160220 MW;  B06B0FA359CD20B4 CRC64;
     MQQVATVHGG EPNPLDSTGL CLLSLDGGGV RGLSTLYILK GLMDRLNQAR PEGSPAKKPC
     EVFDLIGGTS TGGLIAIMLG RLEMNVDDCI LAYIKLMKMV FGKPSKRGLS SLFGKIEPRF
     DANKLEGAIN EVISGCGAKP TDLFNDQADR GCRVFVCSIT QETKEIVRLR SYPMRNKPGI
     PATICQAARA TSAATTFFEP ASIGARRFAD GALGANNPVD EVEGEASDIW CEETGDLKPL
     VKCFISIGTG HPGKKAMEDN LLKFVSKTLP ALVTQTEHTE KRFIAKWRQH YDRKRYFRFN
     VDQGLQDVGL AEYQEQGLIE SATEGYLDHQ TVAFRVRDCV ENLKSKQSAT NLDYTAEIQG
     YQKSLALLEQ WQGRARWQVP FERNTKFTGR EELLNNLTQK LQQESDATTK IAITGLGGVG
     KTQLVLELAH RVRERCAVCW IPVNSLANLQ TAYRKVAQNL GLPGCDEIGV DILEIVQTYL
     SDETIGPWLL VLDNADDIEL CTSPLTSEAG TKRLIDYMPR SRHGAIIWTT RDRKVATGVA
     RENVMTVQQM DESGASKIMR KYLIDPSRIK TNEGLLPGLL RKLTYLPLAI VQAASYINET
     GESLKTYEAL LSSQDDEAIE LLGEHFEDDG RYSGIENAVA KTWLISFEQI RRRSSLAFEY
     LGFMACVDPK DIPRSLLPPS ERSSPKQQTD AIGILNAFSF ITRHGDGSAF DLHRLVHLAT
     RGWLKKNGEL PACHKQAVVR LSELLSDISQ TNRVHWRSYI AHAQYAVGGD EKKCSKEEVN
     LAEMCGDCLS YDGRYREAER MYQIVVGYRE SVLGSEYPDT LTSVSNLGSV LSRQGRYEEA
     EAMHRRALQG YENVLGLEHP DTLTSVSNLG SVLDSQGRYE EAEAMHRRAL QDRENVLGLE
     HPSTLTSVNN LGFVLSQQGR YEEAEAMHRR ALQGYVNVQG LEHPDTLTSV SNLGLVLDRQ
     GRYEEAEAMH RRALQDRENV LGLEHPNTLT SVNNLGSVLD SQGRYEEAEV MHRRALEGYE
     NVLGLEHPDT LTIVSNLGSV LSQQGRYEEA EVMHRRALEG YENVLGLEHP DTLTSVSNLG
     LVLDRQGRYE EAEAMHRRAL QDRENVLGLE HPNTLTSVNN LGSVLDSQGR YEEAEAMHRR
     ALEGYENVLG LENPDTLTIV SNLGSVLSRQ GRYEEAKGIH RRALQNQEKV LGLEHPDTLT
     SVSNLGLVLD SQGRYEEAEA MHRRALQDRE NVLGLEHPST LTSINNLGFV LSRQGRYEEA
     EAMHRRALQG YENVLGLEHP DTLTSVSNLG LVLDRQGRYE EAEALHWRAL QDRENVLGLE
     HPSTLTSVNN LGSVLDSQDR YEEAEAMHRR ALQDRENVLG LEHPSTLTSV SNLGSVLSRQ
     GRYEEAEAMH RRALQDRENV LGLEHPDTLA SLSNLGSVLS RQGRYEEAEA IHWRRP
//