ID A0A1V6Q5T6_9EURO Unreviewed; 844 AA.
AC A0A1V6Q5T6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Proliferating cell nuclear antigen {ECO:0000256|RuleBase:RU000641};
GN ORFNames=PENANT_c013G05403 {ECO:0000313|EMBL:OQD84242.1};
OS Penicillium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD84242.1, ECO:0000313|Proteomes:UP000191672};
RN [1] {ECO:0000313|Proteomes:UP000191672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC and is involved in the control of eukaryotic DNA replication by
CC increasing the polymerase's processibility during elongation of the
CC leading strand. {ECO:0000256|RuleBase:RU000641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000641}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|RuleBase:RU003671}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD84242.1}.
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DR EMBL; MDYN01000013; OQD84242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6Q5T6; -.
DR STRING; 416450.A0A1V6Q5T6; -.
DR OrthoDB; 118939at2759; -.
DR Proteomes; UP000191672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR GO; GO:0017022; F:myosin binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.10.150.10; DNA Polymerase III, subunit A, domain 2; 2.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR026859; Myosin-bd.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352:SF3; MYOSIN-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR Pfam; PF12632; Vezatin; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
DR PROSITE; PS01251; PCNA_1; 1.
DR PROSITE; PS00293; PCNA_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003671};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|RuleBase:RU000641};
KW Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..433
FT /note="Myosin-binding"
FT /evidence="ECO:0000259|Pfam:PF12632"
FT DOMAIN 591..709
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 714..839
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 93062 MW; 5C16F89BABF9380E CRC64;
MESLVYENSP LAEYLEGEGG HQESWPVEEN QSDDDHTSAF DFAPRGASKF QTRVRNKLPK
PLDLRGTPQG EFAGKLYDAC SSALNVRLPR SDNERFLEQF GYVIVASQLL NEHSAPSYTS
ASDVLSATQP TALPSLSTTF GIQGAIVTAC TSFSIAWLLH WSRSRTGSGL NPKKVGVLLI
LVPVLGVLFY AFAKRQWLKY LRHQAVDAAG TFIGNAQGFD SAASASVVFI QEVELVSRGY
RISTPLPPIS RLEDQIQTRR CLRLRRTVSE CFYSMLERYV RSENTLRPLT DEANLAKYYD
IYDIGLEELA AIESSLSQRA NDDQYSLRAL RDLFGKLYSV RKSVLCCLLA LSADGGGSDI
GRWSSAVEEM RELAAVTGDS MLKMTAILNE EDRDNIPPSP LPSASVSPSK DYLRAQIRRF
SSLSQGVRAL HAKMHIVSEE SHASLERPDS ADYEAALLTQ YDSVGGDLRA LLQEWEAGKA
ALVNQDRLSV DRSRPPSTLL MPMSPTPSLG GSTAVEGSPT DALKALNGEG RPDLTQTYDD
EEIFEAVVLP ASRNKRVSLT RDERLARVRE DRARQATARE KVDANTNMLK ELEMASLLKR
VVDAIKDLVQ DCNFDCNDSG IALQAMDNSH VALVSMLLRA EGFSPYRCDR NIALGINLLS
LTKVLRAAQN EDILTLKAED SPDAVNLMFE SAETDRLSEY DIKLMDIDQE HLAIPETEYA
ATVEMPSAEF QRICRDLNAL SESVVIEASK EGVKFSCQGD IGNGSVTIRQ HTNVDKPDQN
VAISLSEPVA LTFSLKYLVN FCKASNLSSS VILHLSQEVP LLVEYGLGSG HLRFYLAPKI
GDEE
//
