ID   A0A1V6Q5X6_9EURO        Unreviewed;       891 AA.
AC   A0A1V6Q5X6;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=PENANT_c012G00690 {ECO:0000313|EMBL:OQD84649.1};
OS   Penicillium antarcticum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD84649.1, ECO:0000313|Proteomes:UP000191672};
RN   [1] {ECO:0000313|Proteomes:UP000191672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQD84649.1}.
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DR   EMBL; MDYN01000012; OQD84649.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6Q5X6; -.
DR   STRING; 416450.A0A1V6Q5X6; -.
DR   OrthoDB; 2786196at2759; -.
DR   Proteomes; UP000191672; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          545..755
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          24..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   891 AA;  99038 MW;  C5667337CA6AC565 CRC64;
     MLSTVPLNVG RRRVFGSVFS PASLEAPTKS KSNSEHETDR TPTSSFHSST GSTSTFKADS
     LPTSFATVGG STDSPNEETL EQARLAASEF LSVPNLGFQL LYDYRNTDGS EVLKQWNRLS
     PPSKETAEAL ECLLLRSPEK QGLLRTIVNC LQLARRIYLA PVVRYLLPLI PTPHQAGFLA
     QLQRAFHTVV SYSLPWQQIS PLLTSEITRD ATTILGIDTL DGDSDMEKMS IDEMEVDRAY
     SVSYKDWRRE TTEGRAHMMD EGEDHRVAIS RDRLLAFLNG LQLVGLGAEK AQKVFARVMN
     VMMSDFISAA YTGQWDAPTS APHHLRQWIE NVFARLAVQV LAIIHSEQSG THSGALDVSF
     RDVEKWQEVG IARLGALRVS ELFDVVVEWP ASSGAVEDLR HFTTHTTSRT HVTQSFINML
     QQRLLHPGAS TVEILQVYIS IIRAFHLLDP KGVLLDRIAR PIRRYLRDRD DTVKVIVGGL
     LADSTAPNTG DTLAELSTEL TKVHQHSMRG NKGELDFDDL NWVPDPVDAA PDYRKSKSAD
     VIDSLVSLFD SKETFVKEMQ TLLADRLIQN RKNYDQEITV LELLKVRFGD SALQACEVML
     RDISDSRRLN ISVQKQSHTK PRSAAMANRL VPPDSTDLHA KILSRFFWPE IQEQEFKVPK
     EIAKLQESYA TGFEALKASR KLNWRNGLGQ VTVELELENH SFTGEVTTWQ ATVIYAFNSD
     TDTDPNEPAT KSVTELSDTL SMTPALVRSA CLFWVSKRIL TEPHRDTFRV LEILPSEHEA
     HGSIIAGPEG AEDEDDDDAN AAAAAEAAAA AAAKESAEAA AMEKMNLHWQ FIVGMLTNQG
     PMPLQNIVMM LKIVVPGGFP FSNEELREFL GGMVSKGKLE VVSGGSYKIV H
//