ID A0A1V6Q891_9EURO Unreviewed; 1107 AA.
AC A0A1V6Q891;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENANT_c010G04540 {ECO:0000313|EMBL:OQD85445.1};
OS Penicillium antarcticum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD85445.1, ECO:0000313|Proteomes:UP000191672};
RN [1] {ECO:0000313|Proteomes:UP000191672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD85445.1}.
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DR EMBL; MDYN01000010; OQD85445.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6Q891; -.
DR STRING; 416450.A0A1V6Q891; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000191672; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..76
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 638..758
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 818..1061
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 214..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 123805 MW; F9B82A9CCC20C382 CRC64;
MEQSEPPRPV FHNYLRAFYP FHPAGNVSPS TVTLPLDQGD IILVHSVHTN GWADGTLLDS
GNRGWLPTNY CEAYDQMPMR PLLKALTDFW DIIRGGCGSS LKDFGNQDLM RGPIAGVRFL
LEKSECLTRE SPLVRRFDGL RRIRKALLSD LSSLVKTAKK FQEVANGTPS EDEVEGILDE
MLLKAFKIVT RGVRFLDVWN EEVGLSRTIA ELESNEPRDQ YDMPPTPASE SFSCETEHPE
RNESRMMESR MESRMESRMM ESPQMSRSRM DMSRASMRTE SLDHPPRPVS VATKRVSVSH
RMSFSGPSAS IRAQNLASER LGTTYDAFLG VLGSFIGLHM QSRSSTELVV TTQQAVQSCR
ALLNVVESVC EHDTQRSVLL DQARESMCEK LSELVHAARD VFCPAQSSDE DLVFMPDEGK
RLVDAATDCV RAAGNCLARA RLVLEQIGDI ELDPENTETE LEQKPQERQE ISLRLPPPPL
QIPSTTYSPP TPALTDATTP SSFQSHITNS PANLSALSSL PNSAILPTHL ENMASFSSTD
SGYPESHAKS DMTESFGRGV TSNGSSFTYN RHARDSEMSG VSQTSTRATS PDIGGSFQGS
FHGPSLKESV SHSTLAEENE ETEAHLLEKT YAHELIYKEG SVMGGSLRAL IEKLTAHQST
PDALFVSTFY LTFRLFATPL EFAEALAERF EYIGDTPHAA APVRLRVYNI FKGWLESHWR
HDRDNIALDF ILHFARTRLV VDLPTAGKRL IELGEKVSAV HGPVVPRLVS SIGKTNTSIA
SYIHPDTPLP PPVLGKKETN LLKSWKNNEA SLSILDFDPL ELARQLTIKE SRIFCSILPE
ELLDTEWTRK SGSLAVNVRA MSTLSTDLAH LVADSILYLE EPKKRATTIK HWVKTANRCL
ELNNYDSLMA IICSLNLSMI SRLKKTWDIV SAKTKSTLEN LRSIVDVSRN YAVLRQRLQN
HVPPCLPFVG TYLTDLTFVD HGNQSLRTLS IDESKMAVIN FDKHMKTARI ISELQRFQIP
YRLTEVPELQ AWLQNELVRV RSNGEITAQT FYRRSLVLEP REASRSGNTL QSQSSDYNHS
LLDNAKDKFD FLSWTNQSKA KSVPTHG
//
