ID A0A1V6QC99_9EURO Unreviewed; 3024 AA.
AC A0A1V6QC99;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OQD86840.1};
GN ORFNames=PENSOL_c085G10555 {ECO:0000313|EMBL:OQD86840.1};
OS Penicillium solitum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60172 {ECO:0000313|EMBL:OQD86840.1, ECO:0000313|Proteomes:UP000191612};
RN [1] {ECO:0000313|Proteomes:UP000191612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29525 {ECO:0000313|Proteomes:UP000191612};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD86840.1}.
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DR EMBL; MDYO01000085; OQD86840.1; -; Genomic_DNA.
DR STRING; 60172.A0A1V6QC99; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000191612; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901336; P:lactone biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0030639; P:polyketide biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000191612};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2391..2468
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2536..2558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3024 AA; 332460 MW; D553C6AA48A3FCF7 CRC64;
MTGGPHTGEP IAIVGSACRF PGDATTPSKL WDLLKAPRDV LSEIPESRFN TKAFYHPDGL
HHGTTNVRHS YLLSDDHRLF DAQFFGTKPV EANSIDPQQR LLLETVYEGL ETSGIPMEKL
QGSNTGVYVG LMTNDYADML GRDVQNFPTY FASGTARSIL SNRVSYFFDW RGPSMTIDTA
CSSSLIALHQ AVQSLRSGET DVAVAAGTNL LLGPEQYIAE SKLKMLSPTG RSRMWDKGAD
GYARGDGIAA VILKPLSAAL ANGDHIECIV RETGANQDGR TKGITMPNPV AQADLIRTTY
ARAGLDLSKP TDRPQYFEAH GTGTPAGDPV EAEAISTAFF GKAAKYHRDG NHEDPLYVGS
IKTVIGHTEG TAGLAAVLKA SLALQHAIIP PNLLLNELSS TVLPFYSDLE ILQVAKEWPE
LPESTPRRAS VNSFGFGGAN AHAILEAFDS RLHARGRNAA DGSSVAVSPF NFSASSEKSL
LTNIAAYSAY LRNHSDINIR NLSWTLNSRR STLPVRLSVS ASSPGELAAR LDEAAVSSTI
TLNTQTGSIR EPKLLGVFTG QGAQWARMGA ELVENLPMIS DCITRLDRSL QELPTEHRPV
WSLREELVKD KSSSRIGEAA FSQPLCTAVQ IALVQLLRAA NVKLTAVVGH SSGEIAAAYA
AGYLNEEDAI RIAYYRGWSL QYATGQVGQK GAMMAAGTSF EDAKELCEMP SLENRICVAA
SNSSASVTIS GDADAIDEAR ETLEDEKKFA RLLKVDKAYH SHHMLSCAAP YIAAVRKCGV
AIQRPPSGSA TWISSVYGDS IDNVSDNLAD TYWINNMVKP VLFSQAVTYA VGASGPFDMA
LEIGPHPALK GPAMQTIQEV SGQVLPYTGT LNRGKNDREA FSSTLGALWI ALGESVVDFA
GFEMKTMQKQ SIPQLIKGLP SYSWDHDRVY WHESRSSTAM RTEGEPFHAL LGVKCPDGTD
NELRWRNYLH PREVPWLAHH QVQGQMVFPA AGYISAAVES VVQKYGLVSV QLIDFHDVVI
GQALVLEENG GVETIFRLSI DQVQDNCVSA SFSCHSDANK GSSSMSLHAS ATVQIILGDP
KHDILPPHAQ PQGSFLDLEG DRFYNSVSEL GFGYTGPFQA LSTLRRKMDE ASGFIAVPVD
AETETPLIIH PASLDGAIQS IMLAYSFPGD GRLRTLYLPT RIDRLRLNPT ACAVLGAPGV
DLPFYSAVTD ARFAELSGDV DIFSADGRHT LVQLEGLHTT PLSPLTSTND VPFFTEVIWD
VDRPTGWQSK KAEDMFPQDR SLALDLERVA HFHFKKLQNS LELSDRANTT LNYTHLLSYA
EHCTTSVANG KHKFAKPEWA NDTMEDVAPI LDRHSDSIDI KLLSAVGENL SAIIRGDMNL
LEILMHDHML AEFYAKTFGI DAYLDAVAQA ARQIGHRYPH VNVLEIGAGA GTTSDRVMRA
MGSSFASYTY TDILDSQFDD ARERFSDYQS RMAFKVLDIE KDIGEQGYEE GCFDLVIAPL
ALYATRKLEV TLTNVRRLLK PGGYLVTLEL TNSDVMRFGL ILGGLPGWWL GYEEGRTLSP
CVSEENWEEL MQKAGFSGFE ALVSSSKTLP VPFSVMVTQA VDHRVNFLRD PLAANHIPLG
VDSLTIIGGK TSLTADMVAD ITTAVRPHYG NIYTASSLGD LVSANLPVMG SVISLIELDG
PVLKHISPEN LKSFQELFKQ SKNVLWLGHG AQGENPYGNM FAGVQRTLAM EMTHLHIHFL
NLHSLHDADA NIIATKLLQL EAAEIWDQAG QLDGILWSNE RELVLQNGHL KVPRFRLNSG
RNDRYNSSRR LIINKVERAG SVVTIQPGEI GYQIEEKDPR ISSSFPDDVS IDVTHSLLRA
VRITPSDNYF LVVGKNARNG ERVIALSHTL ESQVRVPHGL TVRCGDSEEL GIRSMLTLYF
HFLAFSMLQQ LHSGMTLAVL DSEVSFAPVL TKYANEKGIQ LALLTTKEGH CSLPWIRIHP
NSTRREILSK LPVNVSRLVN MGGSSDMATL LRECLPTECH FESENTLTAN CSRSQYTSDR
GQLAMQLQNS WTRAQHDLMP VNMHKFVPLG LEDLIRAQST LMQQSLVAWG ESQLAVQVRP
ATKKVKFSKD KTYWLVGLTG GLGLSLCQWM IGQGARYIAL SSRNPNIDDQ WLQRMAANGC
TVRVFSNDIT NRESVQATHR NISETMPPIA GVAQGAMVLQ DTMFIDLDLS RLEKVLRPKV
EGSILLDELF PEDTLEFMVF FSSMAAMTGN PGQVAYNAAN MFMASLAAQR RNHGLAAHAI
NIGAIVGNGY VTRELNMGQQ SYLYRVGHSW MSEQDFHEVF AEGVLSCLDR VGSAELCCGL
RIDDDESKSW VSNPMFQHLV YKNSNLVVAD NKGKSGVLIK TRLFEATSNQ EVIETLQDGF
VLKLQSALQA DPNKPMLDMS PDELGVDSLV AVDLRSWFLK ELGVDMPVLK IFNAASIRDL
LATAAEVLPE SLIPNFIPGD QAVNPPAHHQ PNTSVAAKAA APAALPVDKI VPESRAGSME
LKFALPDATN AYSGSSATSL ITGDSNSENN DDSSSSLFTD YGEMGPAKRE IQRTVPMSYG
QSRFWFLEHL VEDKTAFNIT PSFELSGRLK IEEFGNAVQT AAQHHEALRT FFFTDDERNH
MQGIWTKSTL QLEHVAISDV TEVKEASKQM EAHVFNLSDG EIMRVRLLSL NPEKHWIIFG
FHHINMDGIS FEVFWSDVEK AYQGQPLSED GLQYPDFTMR QLHEYEQGAW GGDLTYWRAQ
YTEIPPTIPL LPFALQPMRP KVAQFGSHTA QIRLDASLSD SIDRCCRMFK STPFHFHLAV
WKTLLLRFFD IKDVCIGLGD GNRTDADILR SMGLFLNLLP VRFSQQPGQS FGESLKEVRN
ITQGAFSHSR VPFDVILTEL NVPRSASHNP LCQTLFNYRP KAEQSRSFCG CLADGALLGG
GETSFDLGLD VGNVGASETL IHLSAQKSLY GMEHAEILLS SYVNLLRSFL QNPATRVTWP
ELHPKEDLQE AVTAGRGKSI NYPW
//
