ID   A0A1V6QCB2_9EURO        Unreviewed;       671 AA.
AC   A0A1V6QCB2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=R3H domain-containing protein {ECO:0000259|PROSITE:PS51061};
GN   ORFNames=PENANT_c007G03523 {ECO:0000313|EMBL:OQD86662.1};
OS   Penicillium antarcticum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=416450 {ECO:0000313|EMBL:OQD86662.1, ECO:0000313|Proteomes:UP000191672};
RN   [1] {ECO:0000313|Proteomes:UP000191672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 31811 {ECO:0000313|Proteomes:UP000191672};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NFX1 family.
CC       {ECO:0000256|ARBA:ARBA00007269}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQD86662.1}.
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DR   EMBL; MDYN01000007; OQD86662.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6QCB2; -.
DR   STRING; 416450.A0A1V6QCB2; -.
DR   OrthoDB; 1412at2759; -.
DR   Proteomes; UP000191672; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06008; NF-X1-zinc-finger; 2.
DR   Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR   InterPro; IPR034078; NFX1_fam.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR000967; Znf_NFX1.
DR   PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR   PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR   Pfam; PF01424; R3H; 1.
DR   Pfam; PF01422; zf-NF-X1; 3.
DR   SMART; SM00393; R3H; 1.
DR   SMART; SM00438; ZnF_NFX; 5.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   PROSITE; PS51061; R3H; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          402..466
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   REGION          523..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          593..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..630
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  72699 MW;  477E1213D77A7382 CRC64;
     MVRRTNGLAA LAVEILAVVL SIVAYIPARK TAIRKIHTLL IAHDHQMLLT VALACGRTDN
     MSICHQGAVE PPQCPRQCKA TLHCGRHTCT ERCCPGEQKA LERQAARRKL RPHLRPAEED
     IEAEHICTRI CGRTLKCGRH TCPELCHKGA CNTCREAVFE EIACNCGRSV LYPPQPCGMK
     PPPCHYPCER PKACGHPQAA HNCHTDEENC PKCPFLTEKA CLCGKQVLKN VPCWLADARC
     GQVCKQPLKC GSHFCRKDCH RPGDCEDASK PCTQACGKTK TICGHPCTDA CHAPYACPEK
     TPCSAMLTVT CSCGRLRQQR RCNAAKAVTS KGQIQSPQRQ PELTPLSCDD ECTRLERNRS
     LASALGVDIN QQTTAQTITA ENLPYSEETL NQYIKLASSA PLATLQTIES NLHSLAAADK
     STRSFRFQPA KPTLRAFAHS LAADWGFVTE SHDPEPHRHV FVLKPVAWTP PLFGMGSSST
     IGIGGMSVRE CVKLRERERT KEQEARRAAA LEAKAARESI KAQANAGDGW AQVASRSKGG
     SGASTRSSTP LQNSFVSKSI YSALDGDEGA KKERLVLRSG VGAGKSLRAK QPVPQVVDNW
     EDAEEAAEEK EEQLEVGREQ KTEAVTHEDP QGKPEAGAGA ESDTPKEDGP TPAPALAPAE
     EEASSATDVA V
//