ID A0A1V6QCK3_9EURO Unreviewed; 3928 AA.
AC A0A1V6QCK3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENSOL_c081G11659 {ECO:0000313|EMBL:OQD86944.1};
OS Penicillium solitum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60172 {ECO:0000313|EMBL:OQD86944.1, ECO:0000313|Proteomes:UP000191612};
RN [1] {ECO:0000313|Proteomes:UP000191612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29525 {ECO:0000313|Proteomes:UP000191612};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD86944.1}.
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DR EMBL; MDYO01000081; OQD86944.1; -; Genomic_DNA.
DR STRING; 60172.A0A1V6QCK3; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000191612; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901336; P:lactone biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0030639; P:polyketide biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000191612};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..437
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2351..2426
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3490..3570
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2436..2497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2467..2482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3928 AA; 429907 MW; 86323C2B1F556D28 CRC64;
MSPSHNEPIA IVGNACRFPG DATSPSKLWE LLKEPREVAR PIDRFAASSF YHQNGHYHGA
SNVRDAYLLS EDPRYFDAQF FNIPPGEADS IDPQQRTVLE TVYEAVESAG LVLEDLRGSD
TAVYVGVMCD DYGNICYVDQ EAVPTYAATG TARSILSNRV SFTFDWRGPS MTIDTACSSS
LVAIHQAVQV LRSGNSNVAV AAGANLIFSP NMFIAESNLN MLSPTGKSQM WDANANGYAR
GEGIAAVIMK RLSDAIRDGD HIECVIRETG CNQDGHTPGI TMPSHEAQTK LIHDTYRRAG
LDLSKPEDRP QYFEAHGTGT KAGDGVESKA IYHAFFPEGQ TTDESLWVGS IKTIIGHTEG
TAGIAGVMKA SLAIQNKTIP PNLHFKTLNP EIIPYYGKLQ IAKIAQDWPA LPAGAVRRAS
INSFGFGGTN AHAIIEAYEP EVCPVQAEAV VKAAIALPLT FSATSENSVT NLMTKYLEYL
TENPDADLTS LAFTLHDRRS TFAYRSHIAG QSVEEILPKL QNAAEEQQSG NSASIIRGTS
AKKHLLGVFT GQGAQWATMG RELIRASKLA QDIIGKLEQS LAELPASDRP SWSLMEQLMA
DPAQSRIAEG ELSQPLCTAV QVVLVEVLKL AGITFDVVVG HSSGEIGAAY AAGFFNATDA
IRIAFYRGRY AFMAKGPEGQ KGGMLAVGTT LEDARELVEL PSFEGRVSVA AYNSDASVTL
SGDLDAIEEV KEVLDDERVF NRQLKVDTAY HSHHMIPCSA KYYEALDNCK VQILKPSGET
KWYSSVYDGK LMEPCEELKH TYWVDNMVNI VLFATSLESA LNNTVPQPTQ VIEVGPHAAL
KGPASNVIEE VVKAALPYTG TLARGQNDVN AVASTLGYLW AQFGRSSADW KGYSQVFSSS
IPTILQELPS YPWNHDRLFW YEARKSRVNR LRQDPAHVLL GTRTDSINER EYRWRNYISS
KEIPWLSGHS IQGQTLFPAA GFLVMAVEAA RVVGRDQAIH AIELQNSQIH RALAVNEDKG
IETLFTLSNV TSVQTGAGTS TVTANFACDA CLQKGSDVFT SIASGKLIMS LGTPSSSALV
EYPKEAGLGM LDVDCEEFYA YLASIGYNYA DLFRGITSMS RCCDLAQGEI ITSTASQSGP
MDEFLLHPST LDVAFQAIFA AISYPGDGAL WALHIPTTIR RVVINPVICP MKGGLDEKVR
FSATSNRADD GTFSGSVDIF PVHSDHSLCQ VEGMEVSPVS PPTAKNDRHM FGHTSRWLST
PDAEAVAKPV SITTEQEQEH QLLDRLALQE LRKMVASGNS EHAHLRTWAQ GVLKVAGTDA
STGQNDNSSV TVDEASAADL AVLKALGSDE SGLLNKFYAS AFGAAEARSS LISLVHQISR
RYPHMHIMEL SAGNGAATKP LLETLGALCS AYTVTDSTDE HFAALNKEHG DDLFTQTLDL
DQDLEEQGFS AASFDLIIAP AGLHNVQDRA QTIQKLRWLI RPGGFLFVQQ ITNASAAHVG
LTVASLASQT EVPELSEYDA LLQDAGFSGI DSVTPDSVSP FSVFVSQAID AQINAIRAPL
TAGNKTTIDQ ILLIGGRRFQ TSRLIDNIKN ALAQYCDNIT SIQSMREFKP SLLASRPLVL
SLTELDEPFF QDLTDQKYKA LQTLFFRSRY IVWATRGANG DNPYANVMKG VVRCLLIEIP
HLHCQMFNIE GKVKIKQHAT ILAEQLLRLH IADGWKDKIP AYSALWTSER ELMLVDDKLH
ITRYDSEAEL NDHYNGLRRR VVADVSTADR VVAITADRML QQFRLNPQAP IGVEEAKVSV
NVEKSLSTAF KVGDLGYFYL SIGTNKETGE TVLALTDQHQ SLLTVPESRL LAVNVAASER
RTLLVSVGAT LLASALLEKS TASDRLVFHE APTILAELLR EKARKTGAQV VFTTTDKETT
DYWQHVHAYT PGRELSRLVQ ANTSLFVNFS PASEGSEVVN RLKAQLPFRA RCRTLSDYLP
SQSVLYSDTT EAQLAKALKD AHDNAVSEAS SVAFGQVANT FVQQLAADQT LSEPLTTMDW
TDPTPFLANL TLAMDEVRFR SDRTYFLVGM TGSLGLSTCE FMMERGARHF ALSSRRPNID
QRWLDKVETK FGASVKAYPL NITSRESLQG AYKEICATQP PIAGVANAAL IMRDGLFMES
NATTMNEALG PKIDGTIYLD ELFANVDLEF FILFSSLVYI TGNIGQTSYA AGNGFMVSLA
HQRRQRGQCA SVMNLGGING IGYITRTDHN ILNRLDIMGY GIMSELDYKY FFAEAVMAGP
PDSGRDPEVS AGLKFVNPKT DKNPPKWWED PKFSPYVIDK SAREGGGKGA EGVLSTKAQL
QEAATDKDAF NIILTALQAM LHKKLDLPPS QSVLSDVAIV EMGVDSLVAV DMRSWFSSEF
DHDIPIIKIL GGATLADLVE DTVANLSPSI APNLGGAAAA EEEPNVEAET PAEACTAAPS
DDEPISSDDY TPATTDIDEG SVTGKSSADE KVETDAAPGA PAVVRPDFFR VEKMTPGCSR
FWFLRQYLED ASCFNIIVRT RLTGQVDVAR VQEAVRKVGA RHEALRTAYY VDEEGEPMMG
VMPDSKLRLE VSKITHESEA EKAHKEVSKY NFNIENGEVI RMQLLTVGPR EHHLIFAVHH
IAIDGFSFNL MIRDMDMFYQ GKPVPQIASQ FTDLAIQQRK DIESGRLQDD IVFWKDKYTT
LPDPLPLFPF PGVGGRLPQT KYEHEEVEMV LDSAIAQKIR ILCRQNHCTT FHFFLATFRL
FLTRWLEIDD LCIGIADANR KDIKTLATVG FLLNLIPLRF GGLTGKETFS TLLNAAKQTS
YSALNHSALP FDLLLQELEV PRSSSHSPMF QAFLDYRQLA LKTPPMLESQ TEGESNFGAT
AYDVVLDITD DAASDITIKW QTQKSLYNGR HTQAMMDSYM RLLHHCAKGP AGSIASAPLY
RDEHVAAAIK AGRGPQFDSQ WPETLSFKVD QVSAQFPNDI ALRDGLGDSM TYKTMDRILD
QISEQLVQAG IQPGDKVGVF QQPSAMWICS LLAIWRSGAV YVPLDPRNGL PRLAATCGIV
DPSSVLCDSS TAADVAQLAL PAGASTINVD QVRQANKSPA RRPNLSKGDS SAIIVSSSGS
TGVPKGIEVR HLSLLNLFEG DSQIWNLGRP NTVQQSAYSF DISLDQIFTS LVNGGNLYVA
SQAQRSDPQA MAELIANNQI TYTMATPSEY SNWINYAAPT LSKATGWRRA NVGGEGWNAT
LRDSFATLNL PNLKIQNCYG PAENSVWCTR QPIAYPAEST LIPAGPALPN YSFYIVDKQL
NVVPTGVQGE ILIGGAGTAV GYYKRTDLTN EKFIEDKNAS SVHVAKGWNR AYRTGDKGYL
MIDGTLVVLG RITGDTQIKL RGFRIELEDI EATIVRASNG VLSRVVADVR GEGQESYLVG
FVEFADGYLT DQQKTYLAQL LNQVPLPQYM KPNMLIALDR IPLNSHGKVN RLAIATIPVQ
SQVDDAEIST EVTDTEKAIW ELWQEILPQS VLDGVVINLN HDFFQLGGNS LLTVRLQSRI
REAFGIVVPL PKVMESSKLF ALGALLDNLL ANSGINWDLE TALTDDMLQI PPADASSTTR
KNAQPLTVIL TGASGFIGRH MLERLIQDPK IGRVHCIAHR LLSDELPHRQ KFNAVVASSS
KISVHEGDLN APRLGLSETE FAALAQQADM IIHSGANRSF FTTYDQVQAI NVQSTKELAL
MSAASLRDHR RVVPFHFLSG TEAATIKPAS DGSQGYVASK WASERFLEKY AAQLRLPVHV
HRQLPVPEGR EAQGEELDQI LQEFVDVAAK MTELPNSTTW GGHYDLIPAD RLSRDIVGHA
FTALASTDNQ ISSDNVKQYS HLSSVRMDIA KVVERLGSLP EYAQSDRPKI PAHVWVGKAK
IAGFRYQFST MDMVLQDAEG KGLATLSR
//