ID A0A1V6QEK1_9EURO Unreviewed; 357 AA.
AC A0A1V6QEK1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=PENSOL_c078G12005 {ECO:0000313|EMBL:OQD87417.1};
OS Penicillium solitum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60172 {ECO:0000313|EMBL:OQD87417.1, ECO:0000313|Proteomes:UP000191612};
RN [1] {ECO:0000313|Proteomes:UP000191612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29525 {ECO:0000313|Proteomes:UP000191612};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD87417.1}.
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DR EMBL; MDYO01000078; OQD87417.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6QEK1; -.
DR STRING; 60172.A0A1V6QEK1; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000191612; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF48; HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000191612}.
FT DOMAIN 8..353
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 357 AA; 38211 MW; 7ABFC6239FA8D3C1 CRC64;
MAAARTLRIG LIPGDGIGRE VIPAGRRILE SLPSSLNLKF SFVDLDAGYE TFQKTGTALP
DKTVDTLKKE CDGALFGAVS TKVAGYSSPI VALRKKLDLY ANVRPVKTTA GNSNGKPIDL
VIVRENTEDL YVKEERTIEG PNGKVAEAIK RISEHASFRI SNIAGEIALR RQNIRSASPA
TSTRDQAMVT ITHKSNVLSQ TDGLFRETAR RALAAEKFSS VFVEEQIVDS MVYKLFRQPE
FYDVIVAPNL YGDILSDGAA ALVGSLGLVP SANVGDGFAI GEPCHGSAPD IEGQGISNPI
ATIRSVALML EFLGEEKAAA QIYAAVDGNL DAAQFLTPDM GGKATTQQVL DDVLKRL
//
