ID A0A1V6QXT8_9EURO Unreviewed; 843 AA.
AC A0A1V6QXT8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=PENSOL_c030G07853 {ECO:0000313|EMBL:OQD93816.1};
OS Penicillium solitum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60172 {ECO:0000313|EMBL:OQD93816.1, ECO:0000313|Proteomes:UP000191612};
RN [1] {ECO:0000313|Proteomes:UP000191612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29525 {ECO:0000313|Proteomes:UP000191612};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQD93816.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MDYO01000030; OQD93816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6QXT8; -.
DR STRING; 60172.A0A1V6QXT8; -.
DR OrthoDB; 2315072at2759; -.
DR Proteomes; UP000191612; Unassembled WGS sequence.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR CDD; cd08249; enoyl_reductase_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR45348:SF1; TRANS-ENOYL REDUCTASE STHE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000191612}.
FT DOMAIN 20..338
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 375..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 90194 MW; 437BF919B1EE2ED0 CRC64;
MTFVESPQLP QFQTAVVAQG PGKLGIQHNV PIPTLTSDMA LVKTAAVAIN PADAKMLDYS
AAPGAIHGYD FAGTVVALGE NVRAGLAVGD RVAGFVHGMN CLQPEIGAFA EYVGATADLL
LKIPDSLSFE EAATLGVGMG TAAFGLFHEL RIPASLEQLT KANGDASKGE FVLVAGGSTA
TGTRAIQLLK LAGLRPIATC SPAHFDLALK FGADKVFDYH SADCASDIRA YTKGQLAYAL
DCVSLADTTE LCYKAIGRAG GRYVSLEPFR AAVTQTRPTV EPSWLMVLSL FGHEVALDGD
YGRPARPEYR QFGAEAFAAV QALVDRGLID THPTKIMAGG WGGGSSSTTG VCDRCLRQGA
PCVYSFSLPK GRRSTYAGNA APSDSATSRS AIANPRCTPT YSPIPAPELP AETSSEPVSA
ARTPLLPIPE HLNINACPSF LQLEEPGHEA LRSMAWLENV EFGLGAMGTS TAHGTGASET
QDHTGFDAFL NGTDFEDVHM SDIENMSAWS EQESLKEVYL RHGMPTDQKP VSPPPSQDLG
HPLRQALENP TPPEDTRYNI DLVCIDDGIA QLSQLSSHLY TLCRASHDLT ANIGPCGPES
RRLPLFDDKA LISAITWLAA PNMNINTYPP RPPSFALTGS PSGPLATSTT PENTLINTFS
ASHYLLQVLH QLQTLPIPTT RAPPYPDLDE DVGSQTTSRL RSPSLSSTTT NSSSGMRDSA
GSQHSSTVIR HLIIACYTLV LKMWSVLLVA LQHDAELSTE STSFLNSDKL DKEGDEDTPR
PPLLANMRLV LVVNLSSYLV DRLRNAMHTY LSSKITGSAD HGLSELESEF RQPLRRLRRT
LNS
//
