ID   A0A1V6R1L2_9EURO        Unreviewed;       417 AA.
AC   A0A1V6R1L2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=O-methyltransferase domain-containing protein {ECO:0000259|Pfam:PF00891};
GN   ORFNames=PENVUL_c114G07157 {ECO:0000313|EMBL:OQD95355.1};
OS   Penicillium vulpinum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=29845 {ECO:0000313|EMBL:OQD95355.1, ECO:0000313|Proteomes:UP000191518};
RN   [1] {ECO:0000313|Proteomes:UP000191518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQD95355.1}.
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DR   EMBL; MDYP01000113; OQD95355.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6R1L2; -.
DR   OrthoDB; 2197766at2759; -.
DR   Proteomes; UP000191518; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191518};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          236..386
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   417 AA;  46719 MW;  96D037B14FD20455 CRC64;
     MDLTRLATSI CETAEALSSQ PTIDLQERVE LLRACEKLSA IIEHPNSRLE KATVAISPIV
     AARVAINLGI FDFVHNSGKE EFTSDEIASH TGGDPLLICR ILRSLTASGI FNVTLGGTYS
     PGPMVKDLAP GGYLASRIIM NFDIHFQIFA KLPEYLRDNQ YRSPENAYAG PFQYVFDTNE
     HYFNWMKSRP SQMDAFNRTM QAGVERDNSA RWTQIFPVEQ RFQRFLSTSS PVDEELQLVD
     VGGGIGHEIR ILLDTLPSLQ GHFTLQDVPG VIQSMLPELQ ITVPATQTVK AMPYDFFEPQ
     PVTRAHVYFL GRVLHDWPDA QARSILQHIR NAMGKDSVLL IHDRVLPDDA AKVHLSDTIM
     DFNMMALCSS LERTEAQFRE LLGSVGLDLV RVWRPETAGL HRQAVLEAVR ADSVNDK
//