ID   A0A1V6RG58_9EURO        Unreviewed;      1090 AA.
AC   A0A1V6RG58;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=PENVUL_c051G05743 {ECO:0000313|EMBL:OQE00474.1};
OS   Penicillium vulpinum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=29845 {ECO:0000313|EMBL:OQE00474.1, ECO:0000313|Proteomes:UP000191518};
RN   [1] {ECO:0000313|Proteomes:UP000191518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE00474.1}.
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DR   EMBL; MDYP01000051; OQE00474.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6RG58; -.
DR   STRING; 29845.A0A1V6RG58; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000191518; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR007701; Interferon-rel_develop_reg_N.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF05004; IFRD; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000191518};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          24..91
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          386..424
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          480..516
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1090 AA;  121560 MW;  D95A2F50E910CD58 CRC64;
     MDQQRFLQQL QIILDPSQGN LKEATGVLQK EFYNKPESLV FLIQICTSHE DQNLRQLSSV
     ESRSLVAKHW LKVPAAQKPQ IREQLLRSTM GESSSLVQHS IAQIISAIAK IDLNDGEWAD
     LPNLLLQAGN SGNAAERAVA IYILFTILDT LGEGFEEKFQ DLFNLFNKTI RDPESAEVRI
     NTLMSLSKLA MHLDSEEDEA PVKAFQELVP AMVAILKDSI ERQEEDHIMQ SFEVFQTLLG
     CDPALLTVHL KDLVILMNQI AANTEVDEDV RTQAISFLMQ TIQYRKLKVQ GMRVGEELTR
     TALQIVTELG DSAPGDDDIT PARSALGLLD MLSQSLPPSQ VVVPLLNALG QYFNNPDPEY
     RRAGIMALGM CVEGAPDFIS TQMKEIFPMV LQLLADQHPK VRQASLHTVA RLAEDLVEDL
     SSEHARLMPL LFQNLATAMQ EYKGEEEGPT LDIIKAGISA IDAVVDGLDE KDVSPYQAEL
     VPILHNLFKH PDFKIKALAA GALGSLASSA GDSFLSFFDE SMHLLQEFAT VKDSEDELDL
     RASVTDSMGE MAAAAGPERY QPYVEPLMRA TEEALHLGHS RLKESTYIFW GAMAKVYGEH
     FAPFLDGVVK GLYDCIEQDE NDLDVDLGSA AKDLVGQEVT FNGRKVKVAS ADDEDDDDIE
     DVDLEDEDEW DDITATTPLS LEKEIAVEVI GDLVTHTRSS FLPYFEKTIE HVMPLCEHPY
     EGVRKSTIST LHRSYAMLFT IAEENGQMPK WQPGLPLQVQ PAKEVQKFGE ILMTATVKMW
     TEEDDRSTVA DINRNMAENL RFCGPALIAN ETMLHNVIQM VTDIITKQHI CQVEFGPEEE
     TLEAGEESSE FDWIVIDTAL DVVSGMAAAM GQSFAELWKV FEKTILRYAG STESLERATA
     VGVLAECING MGAAVTPFTP VFMKLLLHRL ADEDSQTKSN AAYAIGRLIQ HSNAEAEIIK
     EIPTILARLE ACLQMDVSRL QDNATGCVSR MILRYRDSVP TKDVLPALVN ILPLKNDFEE
     NEPLYRMICQ MYKWEDATIR ELTPSLLPVF QSVITGDEDQ LEDERRAELI ELVKWLNQMQ
     PGAAPWVEQL
//