ID A0A1V6RKZ8_9EURO Unreviewed; 950 AA.
AC A0A1V6RKZ8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN ORFNames=PENVUL_c040G08554 {ECO:0000313|EMBL:OQE02208.1};
OS Penicillium vulpinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=29845 {ECO:0000313|EMBL:OQE02208.1, ECO:0000313|Proteomes:UP000191518};
RN [1] {ECO:0000313|Proteomes:UP000191518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE02208.1}.
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DR EMBL; MDYP01000040; OQE02208.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6RKZ8; -.
DR STRING; 29845.A0A1V6RKZ8; -.
DR OrthoDB; 37872at2759; -.
DR Proteomes; UP000191518; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 3.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191518};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..950
FT /note="ER membrane protein complex subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012415616"
FT TRANSMEM 919..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 728..948
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 950 AA; 102499 MW; D206747ABF266EF0 CRC64;
MRLQAALFFA ACLSPAAAIY SDEVNHIDFH HALLGTPSPD STFFLKPSPS SNASLLYTLS
DKLLVGAVNP RDGALVWRQN ISRSADSPAH AAGLLRGLDG NDAVVAAVGN YISSWSAQDG
KVGWENRVSE GVVTDLELLE LEDATATSGV RDAIAVVTSE GTGIVRRLDG NTGKTVWEYK
DGSGDVPFQV SSSSTEVFYI SLQSAILKGF KIKVTVLDPL TGRQTRQQIL NSEADVVTPE
SVLYVGANSA SPIIVWADKS QKSLKVNVIG TKEITSIAID NTSGSEIRQI TVHAPHKLNA
LPHFLVHFAT EAGAWSEVYH VDLMSAKVTK AYSLPYLPGQ SLVAASVIDA NVYFTRVTDS
ETVVVSSASH GILGRWDLQK PSSESVLHSV SEVVAKGKSV AVRSALFRKH GDWQLIRNGH
TEWTRHEGLI DAVAATWAET DAQEDLAHEL EVEGHETLYG AYLHRVKRHI RDLEHLPEWL
KHLPQRILSS ILSDEVSNLD SFGVAKSVIV ATKNGRVYAL DTGNHGAVLW GVQAVETSQW
NVKAILASPG VATIYSDDGS SVTVDVSTGE IVSRIEPSNS KLHSIAVFGS QDGSSLATVG
VREDGTPVTA SVNEDGFLVT TSIDGRVLGW FAKDNKTPVW EFVPPSGQKV VKATARPAHD
PVASIGRVLG NRSVLYKYLN PNLALVTAVN EQTHTASFYL LDGVSGKVLH ATTQEGVDST
QPIASVMSEN WFAYSFWGDV DGNESSAKGY QLVISELYES PFPNDRGLLD PATNYSSTAI
LPLPHVISQA FMIPESISHM AVTQTRQGIT TRQLLCTLPS SNSIVGIPRP VLDPRRPVGR
DPTPAEAEEG LYRYAPFLDF DGKWYLSHTR DVAGIKAVLS RPTLLESTSL IFAYGSDIYG
TRATPSQAFD ILGKNFSKLQ LVLTVVALGV GVTVLAPMTR AKQVNALWRA
//
