ID   A0A1V6RPI5_9EURO        Unreviewed;       820 AA.
AC   A0A1V6RPI5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3 {ECO:0000256|ARBA:ARBA00019824};
DE   AltName: Full=Polynucleotide 5'-hydroxyl-kinase grc3 {ECO:0000256|ARBA:ARBA00018706};
GN   ORFNames=PENSOL_c001G07735 {ECO:0000313|EMBL:OQE03682.1};
OS   Penicillium solitum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=60172 {ECO:0000313|EMBL:OQE03682.1, ECO:0000313|Proteomes:UP000191612};
RN   [1] {ECO:0000313|Proteomes:UP000191612}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 29525 {ECO:0000313|Proteomes:UP000191612};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000256|ARBA:ARBA00003798}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00011003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE03682.1}.
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DR   EMBL; MDYO01000001; OQE03682.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6RPI5; -.
DR   STRING; 60172.A0A1V6RPI5; -.
DR   OrthoDB; 5480745at2759; -.
DR   Proteomes; UP000191612; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR   PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191612};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          334..536
FT                   /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF16575"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  89903 MW;  909B9E74CEDA2040 CRC64;
     MVKRKAEKQQ SAGPVSAVAA LAARRARQQQ AQSANVPKDA PQPVVESEPP SKKSRQSLEG
     PGVTETNEEH RGTRTKAAKK QDEPLPAETT PERPVRVSRP QKSELKAEVE DTLKHPEDNQ
     SEKDQVEDAG EMDEDDIASV VGDADGYESP AETPAELQNF PLSKARLNKS NIVYSDESTL
     CIRIKERTNL ALLGHYDLWV KRGVVSLMGA KLHPSSQLHR VYAPSTHSLP VIKCVAGIDG
     DAEVEIKSCT SGISRLRDLS PLYQRIWAGE NTAADKITLK GAAKDSKRTF SVLYTSADDS
     LNRHIRPLHL DKKWSASMKS LSQREGQLRV LICGPKASGK STFSRYLLNH VLSPTPETEN
     GYTNTDGVAF LDLDPGQPEF APMGQVYLAR LRSPFFGPPF THPSLDDSRD GEIVRAHHIG
     AASPKEDPDH YALAVMDLMD QYRSLLEKHP QCPLVINYPG WIFGQGLEVA TWLVRSLGLS
     DVVYMSEKGP SEVVDPLGLA AHEARVPLTI LPSQPTDFVS RSSAQLRAMQ IQSYFHMSHP
     NDLSTPLWSD VPLSRTRPIT VDYAGARQGI LGVMVMGSQI NPDLLHETLE GAIVGVVAVE
     SPKAIMSGMA TSEPPNDEDH ADIDMDSANP GAGNPADLSI ADSIVRTSED LPYLFVGSGS
     CTPLDPKASN CLGLALVRSI DTSSRKLELS TPIPSSHLEK AIEQGHGIVL VRGQLDNPNW
     AISEEYYAAR AAERRYQQST SGPRKAGDSG IEQAHELDPA EHNRTLALLR ERVRRASNVP
     WMTVVEDNSR YQREAAARRE KSLWKLRKKA YPGSESEADY
//