ID A0A1V6RYX3_9EURO Unreviewed; 887 AA.
AC A0A1V6RYX3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=PENVUL_c015G00546 {ECO:0000313|EMBL:OQE06955.1};
OS Penicillium vulpinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=29845 {ECO:0000313|EMBL:OQE06955.1, ECO:0000313|Proteomes:UP000191518};
RN [1] {ECO:0000313|Proteomes:UP000191518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE06955.1}.
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DR EMBL; MDYP01000015; OQE06955.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6RYX3; -.
DR STRING; 29845.A0A1V6RYX3; -.
DR OrthoDB; 1369806at2759; -.
DR Proteomes; UP000191518; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000191518}.
FT DOMAIN 219..363
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 368..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 97427 MW; 15A9DFEB89E9F483 CRC64;
MPIEALPQKT IRAIGSTSVI SDPYSVVKEL VDNALDASAT SLQIEISHNT VDVIQLKDNG
HGISAEDQQH VCKRAFTSKI QTLDDLKNIG GSSLGFRGEA LASIAEMSGV FTVTTRVESE
VAGFFSKYGR NGERIGTQRM SHPVGTTVRI TDFLKHIPVR RQTALKGATR NLTRIKKLLH
AYAIAQPSKR LSLKVLKAKT ENSNWTYAPS VDASLSDAAI KVAGTEVASS CIMKRLSSQN
AARNQRELSD QKEYEAIAFL PKTQFDTSRI NGSGQYISVD GRPLSSSGGI GHEIVKIFKP
YVRAAASKNE STKSVSDPFL CLQILCPQGT YDVNIEPAKD DLLFEDRDVV LALVENLFRD
HYGEIDGREA RTSNQGKESA SRSDRAPGGF ELLMARKPAT DPPTQTRDPE NPFRGAIPHT
PLSQRTLQSK YDFSPVVPSS SKGPESQEEL STARTKRSSF VNPWSISRIN ASFQTSGRGS
NSINQASPVD LSSGSLQGPI GRESQSRGFQ HSPNSDLASP STSRLASGSP VRRRRHHPQG
STDSSPESNR ISSTRRAERE RDRDRYGNGA LDTWFQRTTQ VSLQQDPVEE APTQEPDSPL
SLLAQQRFGS PADSSPNIIH VDAQNDGCSD SPSNNSLTLE DHGDHITEAM DSGRGFPVLE
RWAAQLHEGV THEQSSDLDL EKALDFERRK KEAIQNSRTR FKKNDKPSGS QSAPISHSPH
GNRYLAAKAA LTSSQTSIGE PVSATMLSPH DPRAYLIRQE RDYPIDEPST NDGKARRLLT
SRLPFERIPD GSDLHDLGYT WSVDLSSSSN SFKQNLPEDL YTENENGTTA LSASDLETCL
PLWNTRLMLI MKQQYKNKDE SKPLSVEIDL AATISQHLRS SQLAQPN
//
