ID   A0A1V6RZP6_9EURO        Unreviewed;       828 AA.
AC   A0A1V6RZP6;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   03-MAY-2023, entry version 18.
DE   RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN   ORFNames=PENVUL_c014G08472 {ECO:0000313|EMBL:OQE07261.1};
OS   Penicillium vulpinum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=29845 {ECO:0000313|EMBL:OQE07261.1, ECO:0000313|Proteomes:UP000191518};
RN   [1] {ECO:0000313|Proteomes:UP000191518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC       biogenesis, stability and to maintain vacuole morphology.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- SIMILARITY: Belongs to the VPS16 family.
CC       {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE07261.1}.
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DR   EMBL; MDYP01000014; OQE07261.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6RZP6; -.
DR   STRING; 29845.A0A1V6RZP6; -.
DR   OrthoDB; 1110811at2759; -.
DR   Proteomes; UP000191518; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR   Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR   PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191518};
KW   Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT   DOMAIN          6..408
FT                   /note="Vps16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04841"
FT   DOMAIN          502..810
FT                   /note="Vps16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
SQ   SEQUENCE   828 AA;  92872 MW;  6F6901CE72688C84 CRC64;
     MPSNPLANWE KVGDSFYRKI AVYDAIFEDD VELENYIVAG APYGGAIALY RDESKPFRLR
     DGQGSRSTID VYSCSGQKIN RINWEQATIR GLGWSDKEEL LVVSEDGTVR RYFGLDGEFT
     SFSLGNGAEE YGVRACQFWS SGLVALLSNN QLIAVSKYDE PRPRLLAPCP EGEVSSWALI
     PPAHTLSRSV EVLLAVDKTV FLIDSTEAED KILQDGPFKH ISVSPTGRFV GLFTAEGKLW
     IVSNDFQNKF SEYDSKSRVP PNTVNWCGDD AVILGWEDEI HLVGPNGVAS KYYYDGRVHV
     IPEFDGVRLI TNDTCEFVHK VASVTEEIFR LGSSSPASVL LDSVDQLEKK SPKADENIQR
     IRSSLPSAVD TCIKAAGHEF DAYWQKRLLK AASFGKSVLE LYNSDEFVEM TEKLRVLKAV
     RDYKIGLPLS YEQYLRLTPE GLIERLISRH EYLLAIRVSE YLQIPADKIY VHWASQKVKV
     STVDDEAVCK LIVQRLDGKP GISFEVIAQA AYDEGRSHLA TQLLNHEPRG GKQVPLLLNM
     EEDELALDKA IESGDDDLVN YVLLHLKSKL PLASFFRMIN TRPMASALVE TAARGDDIEL
     LKDLFYQDDR PIDGANVLLS EALHDTDLTS QTEKLHLASQ LLSDSKEPTV VLNQKLVSEA
     SQLLKAQDAL DKDLADHNEF LGLSLNETVY RLVRGGYGKR ANKMQSEFKM PEKTFWWLRL
     RALVAKRDWG ELEEIAKLKK SPIGWEPFYN EILGAGNTKL ASGFVPKCTH LPPAERIEMW
     VKCGMIVKAG EEAQKTKDIN TLELLRTKAS GPAATEIERM INQLRPRK
//