ID A0A1V6S6J2_9EURO Unreviewed; 612 AA.
AC A0A1V6S6J2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OQE09243.1};
GN ORFNames=PENVUL_c007G06201 {ECO:0000313|EMBL:OQE09243.1};
OS Penicillium vulpinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=29845 {ECO:0000313|EMBL:OQE09243.1, ECO:0000313|Proteomes:UP000191518};
RN [1] {ECO:0000313|Proteomes:UP000191518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29486 {ECO:0000313|Proteomes:UP000191518};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE09243.1}.
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DR EMBL; MDYP01000007; OQE09243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6S6J2; -.
DR STRING; 29845.A0A1V6S6J2; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000191518; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000191518}.
SQ SEQUENCE 612 AA; 69045 MW; F7D84F6E92A89864 CRC64;
MHIREKLAKN EAEGKIGISF EFFPPKTAQG VQNLYDRMDR MHGLGPSFID ITWGAGGRLS
DLTCEMVSVA QSVYGLETCM HLTCTDMPLE KVDQALQAAY KAGCTNILAL RGDPPRDKET
WEAAENGFCY AKDLVKYIRD KYGNHFDIGV GGYPEGADDN TDVDQLIDHL KEKVDAGSSF
VVTQMFYDAD NFIEWVKKCR AKGINVPIIP GIMPIQTYAS FIRRSNWTKV KVPPQWMEAL
EPVKNDDSAV RDIGKTLIAD MCRQLIAAGL KHLHFYTMNL AQATQLVLKE LNLSPSDESP
IQRALPWRPS LGLGRRTEDV RPVFWRNRNS SYVARTQTWD EYPNGRWTDS RSPAFGELDA
YGVGLKGTNE QNIKLWGEPK SIKDISNVFV DFLSGKLDRL PWSDSPITTE AHEIQEDLLK
LNQRGFLTIN SQPAVNGVKS SHPVYGWGPK NGFVYQKAYL ELLVPSNLID ELITRIEKND
DLTYHATNKK GELRTNTRDS PNALTWGIFA GREIIQPTIV ETVSFLAWKD EAYLLGEHWS
KCHDAASPSR RLIQQIMDDW YLVNIVDNDF HRSDGLFELF NGLEVKDLNV EVAEKPLTNG
HAEPEQNGVS AN
//
