ID   A0A1V6SNC7_9EURO        Unreviewed;       820 AA.
AC   A0A1V6SNC7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3 {ECO:0000256|ARBA:ARBA00019824};
DE   AltName: Full=Polynucleotide 5'-hydroxyl-kinase grc3 {ECO:0000256|ARBA:ARBA00018706};
GN   ORFNames=PENFLA_c033G04998 {ECO:0000313|EMBL:OQE15169.1};
OS   Penicillium flavigenum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE15169.1, ECO:0000313|Proteomes:UP000191342};
RN   [1] {ECO:0000313|Proteomes:UP000191342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000256|ARBA:ARBA00003798}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00011003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE15169.1}.
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DR   EMBL; MLQL01000033; OQE15169.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6SNC7; -.
DR   STRING; 254877.A0A1V6SNC7; -.
DR   OrthoDB; 5480745at2759; -.
DR   Proteomes; UP000191342; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR   PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191342};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          334..536
FT                   /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF16575"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          733..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  90051 MW;  EE8C6C5DDE367E60 CRC64;
     MVKRKAEKQQ SAGPVSAVAA LAARRARQQQ AQSANVPQDA PPAIIESERP LKKSRQSLEG
     PEATETNEER HGTRTKAAKK QDEPLPAEIT PERPVRATRP QKLEVKREVG NTPKHPEDEQ
     SENDQVEDAG DMDEDDIASV VGDADGYESP TETPAELQNF PLSKARLSKS NIVYSDESTL
     CVRIKERTNL ALLGHYDIWV KRGVVSLMGA KLHPSSQLHR VYAPSTHSLP IIKCVAGVDG
     EAEVEIKSCT SGISRLRDLS PLYQRIWAGE NTAADKITLK GASKDSKRTF SVLYTSADDS
     LNRHIRPLHL DKKWSASMKA LSQRQGQLRV LICGPKASGK STFSRYLLNH VLSPTPETEN
     GYTNTDGVAF LDLDPGQPEF APMGQVYLAR LRSPFFGPPF THPSLDDSRD GEIVRAHHIG
     AASPKEDPDH YALAVMDLMD QYRSLLEKHP QCPLIINYPG WIFGQGLEVA TWLVRSLGLS
     DVVYMSEKGP SEVVDPLGLA AQEARVPLTI LPSQPTDFVS RSSAQLRAMQ IQSYFHMSYP
     NDLRTSLWSD VPLSRTRPIT VDYAGARQGI LGVMVMGSQI SPDLLHETLE GAIVGVVAVE
     SPKAIMGGMA TSETPIDEDH EDIDMDSANP SAGNSAELSI ADSIVRTSED LPYLFVGSGS
     CIPLDPNASN CLGLALVRSI DTSSRKLELS TPIPSSHLEK AIEQGHGIVL VRGQLDNPNW
     AISEEYYAAR AAERHYQQST SGPRKAGGSG SDQAHELDPA EHNRTLALLR ERVRRASNVP
     WMTVVEDNSR HQREVAARRE KSLWKLRKKA YPVSESEADY
//