ID A0A1V6STP5_9EURO Unreviewed; 945 AA.
AC A0A1V6STP5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENFLA_c024G04480 {ECO:0000313|EMBL:OQE17387.1};
OS Penicillium flavigenum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE17387.1, ECO:0000313|Proteomes:UP000191342};
RN [1] {ECO:0000313|Proteomes:UP000191342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE17387.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MLQL01000024; OQE17387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6STP5; -.
DR STRING; 254877.A0A1V6STP5; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000191342; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000191342}.
FT DOMAIN 440..565
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 691..929
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 28..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 105313 MW; 6A0AAC2EEF364D96 CRC64;
MRCSACSLNL HSNQSAVTPI HSVEKLPTAS VMISQQPRRE RALSDRAQAM SATASRPGMG
SRTSSAPAGG FYKLDVARKP GTGTTVEHTL LEEDEGSPIM GEATNGTGLR QKEEETPKSG
FPEVTIAVAG EENAGKTSFV KCALDMKNTP VSPINKKKMS LDGSVYIVHL MEVDLTQVRF
DQDKKIIWPH TGRDRSAPAI DAVLVLHDAT KPDRLSLTTN LIDSLAASDL PFLQVACKCD
VNPEPLEDSE VDAVHDRYEI YRTSFSSPRS QRMCIALVLG AVISNREDLA NNSNISLSKP
SDWHHTRSNS ENPAVFTAAG GPQTASDQVD GDGENPLPTD GNYLQHTSNP HRYARSNSQP
VRPQTPPSGA RLNTRRPSAQ ELHSPNHDNR QQRLHTAWRH SGGSDAFNSF LNMDDEGDDG
QSRPASPGAV VRPKPSSESN SSAETGLSFD ELVDRLISLP ISKQDQKFRS IFLCLYRKFA
APASLLTALI IRFERNETSN DDQLARMADQ LRLLDVMAQW ASDYPGDFAH PKLRKRIIEF
VAVLEKSHFY MFAAKEIGSQ LDSNAEDDDV GWAYGGDSDS DEPQLVETFF DNSGRSSPAA
VTGAGSTTNT YDTEEEQDPI YSMSALDLSS GPHDSTSRLS VSSNTDKSNN ITTQSFTLLN
LEAAQKEALR LELTHKTSLG KLQWRFFMET PEEEFARELT RIDWIMYNSF RPRDLVRHVS
LSGIDKDKVK SLTNVNRMIK QFNHLAFFVA SLILLRDKPK HRAQALEKFM NVAVKLRRQN
NYNSLGAVIA AINGTPVHRL TQTRDLIPIQ TQKEFMRLVI LMSTQRSHFA YRLAWENSFS
ERIPFLPLHR RDLVSAEEGN KTFVGENKSR INWKKFEVMG EVVLGIQRSQ KTPHPQAQKF
DDVERLILDS KLSGDEEDLY ARSLLVEPST GAEGRRKFGW LRSQT
//
