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Database: UniProt
Entry: A0A1V6SWS2_9EURO
LinkDB: A0A1V6SWS2_9EURO
Original site: A0A1V6SWS2_9EURO 
ID   A0A1V6SWS2_9EURO        Unreviewed;       249 AA.
AC   A0A1V6SWS2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   03-JUL-2019, entry version 10.
DE   RecName: Full=Protein-lysine N-methyltransferase EFM6 {ECO:0000256|HAMAP-Rule:MF_03198};
DE            EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_03198};
DE   AltName: Full=Elongation factor methyltransferase 6 {ECO:0000256|HAMAP-Rule:MF_03198};
GN   Name=EFM6 {ECO:0000256|HAMAP-Rule:MF_03198};
GN   ORFNames=PENFLA_c021G08037 {ECO:0000313|EMBL:OQE18421.1};
OS   Penicillium flavigenum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE18421.1, ECO:0000313|Proteomes:UP000191342};
RN   [1] {ECO:0000313|Proteomes:UP000191342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J.,
RA   Nielsen K.F., Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential
RT   of secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that methylates elongation factor 1-alpha.
CC       {ECO:0000256|HAMAP-Rule:MF_03198}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03198}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. METTL21 family. EFM6 subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_03198}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OQE18421.1}.
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DR   EMBL; MLQL01000021; OQE18421.1; -; Genomic_DNA.
DR   OrthoDB; 1494909at2759; -.
DR   Proteomes; UP000191342; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03198; Methyltr_EFM6; 1.
DR   InterPro; IPR033684; EFM6.
DR   InterPro; IPR019410; Methyltransf_16.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF10294; Methyltransf_16; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000191342};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03198};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03198};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191342};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03198};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_03198}.
FT   REGION        1     31       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1V6SWS2}.
FT   REGION       95     97       S-adenosyl-L-methionine binding.
FT                                {ECO:0000256|HAMAP-Rule:MF_03198}.
FT   BINDING      68     68       S-adenosyl-L-methionine; via amide
FT                                nitrogen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03198}.
FT   BINDING     119    119       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_03198}.
FT   BINDING     147    147       S-adenosyl-L-methionine; via amide
FT                                nitrogen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03198}.
FT   BINDING     165    165       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03198}.
SQ   SEQUENCE   249 AA;  27296 MW;  F884F25525D90928 CRC64;
     MIETPMATPP GPESSPPSSP DGLKISESLA PPRELKAAVT TDISFDGLLK EPLLLKEDLK
     DGCGGQLWPA GMALANYLLS RHATDLSDKT IVELGAGGGL VGLAVARGCH LEQPIYITDQ
     EPMFSLMKSN IQLNNLGPNA TAAILNWGEP IPKQIPSKPD VIIAADCVYF EPAFPLLITT
     LQDLLGPNSV CYFCYKRRRR ADMRFMKMAK KAFEMELVRD DPGAEGYNRE SIFIYTIRAK
     RLDQKSGTR
//
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