ID A0A1V6T9R6_9EURO Unreviewed; 582 AA.
AC A0A1V6T9R6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 25.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=PENFLA_c012G06864 {ECO:0000313|EMBL:OQE22754.1};
OS Penicillium flavigenum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE22754.1, ECO:0000313|Proteomes:UP000191342};
RN [1] {ECO:0000313|Proteomes:UP000191342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE22754.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MLQL01000012; OQE22754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6T9R6; -.
DR STRING; 254877.A0A1V6T9R6; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000191342; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07625; BAR_Vps17p; 1.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000191342};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 118..230
FT /note="PX"
FT /evidence="ECO:0000259|SMART:SM00312"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 63936 MW; 54882B58629F60FC CRC64;
MDYSVISTDP DHPTGTSPWG SPRAERGTFP TSNNDIPSSP LPGQEQSADV GSVGNGDPQS
PDLSAQLQSA QLGDPDYPDA HFPFGVHQSP NVQQQQSPTP AQYQTGARQD SRPAAPTYRI
QGKITGLERT GKKDPILRFD VHTNIPKFRT TQYRDVRRTH SEFVKLADHL VSANPEALVP
AVPSPVTPAG AGTEEDEIRI KSAMQRWLNV VLSNEVLIQD DEVVLFVESD FGYSPVLRMK
QPATGVRRKM LKQFAPPPDD TPELQAARPT AKMFYLGSMD SSHKVDRVVK ARRGLGLAEA
DFGVKLGQMS VQETHPGLGA AYRKLGKIVQ TVGDYHAVQA TAEATTLGEP LNYHSSDAFI
VKETLTNRHI LLRDLLQAQQ SARSKRAAAD RLKVSSSVRP DKVDEAINAL EEAQNHEDYL
TKRTQRVTSN LLQEKRRWFD RTTHDLLFSL REYTLRQIEA ERRTLATLES VRPDIRAIDA
SGGLSRLGRE SHPATRRPNM VSSQGPKGDS WSGVPRRNDN VGRSMSGSFT APSLPDDDDE
ANGQGSGKGR NRASSQVGSI AEEDDDRLDA RNAASRLATS TF
//
