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Database: UniProt
Entry: A0A1V6TC24_9EURO
LinkDB: A0A1V6TC24_9EURO
Original site: A0A1V6TC24_9EURO 
ID   A0A1V6TC24_9EURO        Unreviewed;       805 AA.
AC   A0A1V6TC24;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=PENSTE_c009G09471 {ECO:0000313|EMBL:OQE23123.1};
OS   Penicillium steckii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=303698 {ECO:0000313|EMBL:OQE23123.1, ECO:0000313|Proteomes:UP000191285};
RN   [1] {ECO:0000313|Proteomes:UP000191285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 24891 {ECO:0000313|Proteomes:UP000191285};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}.
CC   -!- SIMILARITY: Belongs to the HRD1 family.
CC       {ECO:0000256|ARBA:ARBA00010089}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE23123.1}.
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DR   EMBL; MLKD01000009; OQE23123.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6TC24; -.
DR   STRING; 303698.A0A1V6TC24; -.
DR   OrthoDB; 2912447at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000191285; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:UniProt.
DR   CDD; cd16479; RING-H2_synoviolin; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22763:SF184; E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN; 1.
DR   PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191285};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        43..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          342..407
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          424..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          512..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..700
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..793
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  88344 MW;  BFCE5C0F1081768A CRC64;
     MRLAVYAGAS VALATGVFLK ALHQRANFYS ACVYLSQSSA NLMILTNLCL LATGFILFWL
     QRLLYGRLRP IETEQLYERA WFAVTETCLA MTIFRGELGG WFLVMFISLL VGKVWGWIGE
     GRVEYLEQQP PANPRLFHTR LSSSLVLSVL FNAFMLKYCV DTVIRQPRPD MMVMFGFEFA
     ILTLLSASTT ARYVIVLTEI YVTRQQLKEK MDERRAEIRE ARLEAIREHA RAGESSPPSD
     LPNENDINEL EFDVPGWEGK ARWVFYLDLL TDLVKLIVYL VFFAILLTFY GLPIHILRDV
     VVTIRSFVRR ITDFLRYRNA TRDMNERYPD ATAEEVAREE LCIICREEMV SIQPAAGAPE
     EGAAQPAAGA RPVPERLRPK KLPCGHILHF SCLMSWLARQ QNCPTCRRPV ILTAAARARE
     AAAANANNAG NGHPDRAAGD QLPGQPGVQG NGMPRARVFQ FGPFRFGFGA VRGGDLFNNL
     HQQIHQGNAP LQPAVNANPQ GARQIGFGFG FGRRPPLATP QNLPQQGHPQ QGQPQFQTPS
     LDDTEAQLQQ IEDQISQQIA GIRRNIDHLT HVRNLQRSLQ QAQQSLQEQA GLQPGMPSLT
     TQASGTLPQT GTLGISARQF VAGPASATLT SGDSRLPEGL TLPPGWTMVP LEATDQAGQP
     IPQSVNPTPT INPTNGQSPA QTSQPPVTSA TYTPNANDNV GVRENAGAVP SSAPSSSEAQ
     PASSTLPNWN TSTGSSSVTQ RPADSLSQEW TDVRSDQVPD TNQSTIPSWG TNHTSTNEVS
     EENSISTSKG KGRAATVEET DDTTN
//
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