ID A0A1V6TEP8_9EURO Unreviewed; 514 AA.
AC A0A1V6TEP8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=PENSTE_c007G02983 {ECO:0000313|EMBL:OQE24504.1};
OS Penicillium steckii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=303698 {ECO:0000313|EMBL:OQE24504.1, ECO:0000313|Proteomes:UP000191285};
RN [1] {ECO:0000313|Proteomes:UP000191285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 24891 {ECO:0000313|Proteomes:UP000191285};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE24504.1}.
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DR EMBL; MLKD01000007; OQE24504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6TEP8; -.
DR STRING; 303698.A0A1V6TEP8; -.
DR OrthoDB; 705at2759; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000191285; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR005256; Anth_synth_I_PabB.
DR InterPro; IPR015890; Chorismate_C.
DR NCBIfam; TIGR00564; trpE_most; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000191285};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 40..171
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 229..493
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 514 AA; 56551 MW; 6B45ADEEE3934C00 CRC64;
MAPPIANVPS LETAQEVISK SRNSQFPPNL LPITASIPAD LLTPTLAYLK IAENSRLSFL
YESAATTETI GRYSFVGADP RKVLKTGPGH GPEADPLPYL EEELSQFRVA SVPGLILPPL
TGGAIGYVGY DCVRYFEPKT ARPMKDVLGV PESFFMLFDT IVAFDHFFQT VKVVSYVPIP
ANDADVEVEY RKGQAAIQKT IDTLLQDRTP LPPQGPIKQN QEYKSNIGQE GYENHVKKLK
EHIGKGDIFQ TVPSQRLSRP TSLHPYNLFR HLRTVNPSPY LFYIDCQDFQ LVGASPELLV
KEDRGRIITH PIAGTVKRGK TLEEDTALAD ELRGSLKDRA EHVMLVDLAR NDVNRICDPI
TTQVDRLMVV EKFSHVQHLV SQVSGVLRPG KTRFDAFRSI FPAGTVSGAP KVRAMQLIAE
LEGEKRGVYA GAVGYFGYNI SSADGSSEEP GAMDTCIALR TMMVKDGVAY LQAGGGIVFD
SDPYDEYIET INKLGANIAC IRGAEEKYLS LEGN
//
