ID A0A1V6TGI6_9EURO Unreviewed; 474 AA.
AC A0A1V6TGI6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENSTE_c006G05897 {ECO:0000313|EMBL:OQE25455.1};
OS Penicillium steckii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=303698 {ECO:0000313|EMBL:OQE25455.1, ECO:0000313|Proteomes:UP000191285};
RN [1] {ECO:0000313|Proteomes:UP000191285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 24891 {ECO:0000313|Proteomes:UP000191285};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE25455.1}.
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DR EMBL; MLKD01000006; OQE25455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6TGI6; -.
DR STRING; 303698.A0A1V6TGI6; -.
DR OrthoDB; 1887365at2759; -.
DR Proteomes; UP000191285; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd02922; FCB2_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR000262; FMN-dep_DH.
DR InterPro; IPR037396; FMN_HAD.
DR InterPro; IPR037458; L-MDH/L-LDH_FMN-bd.
DR PANTHER; PTHR10578:SF104; CYTOCHROME B2-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07020)-RELATED; 1.
DR PANTHER; PTHR10578; S -2-HYDROXY-ACID OXIDASE-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF01070; FMN_dh; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000191285}.
FT DOMAIN 1..56
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 108..464
FT /note="FMN hydroxy acid dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51349"
FT REGION 82..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 51888 MW; 7ABDD25DB8903DF1 CRC64;
MPLTRAEIQQ HNNRQSCWVA IHGSVYDVTD EHPGGAKVIL RCAGRDATRD FDSVHSLELL
AETLPETTLR GHIESDELVD SAKAKTTKAN DHTSSPAQTN SNDVPPPPPL NTLINLHDFE
RVAEQYLAPN AWAYYTSAAD DELSKRNNSK AYQQVALRPR VLRKIPRVDT VTSILGHSVA
LPVYMSPVGI AKYAHPDGEC ALARAAGEEG LAQVLANGSS MSVEKVRQSR VTEDQPLFFQ
LYVNRDISKS VESVKRAVKA GARGIWITVD SPVVGKREMD ERMNLDISAT DSNAQGEGVA
KVMASSISPF IDWDILNWIR DLTDLPVVIK GIQCVEDAVL AYEYGVQGIV LSNHGGRSQD
TAQSPLLTLL EIRKFAPHIL DGKMQIFIDG GIRRGTDVLK AIALGATAVG LGRPFLYSLS
AGYGENGVRR MVQILRQEIE ANMTFLGATC LKDLRPEMVN TSRLERDLVG SVKL
//
