ID A0A1V6TME8_9EURO Unreviewed; 852 AA.
AC A0A1V6TME8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENFLA_c006G05196 {ECO:0000313|EMBL:OQE27164.1};
OS Penicillium flavigenum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE27164.1, ECO:0000313|Proteomes:UP000191342};
RN [1] {ECO:0000313|Proteomes:UP000191342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE27164.1}.
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DR EMBL; MLQL01000006; OQE27164.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6TME8; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000191342; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191342};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..188
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 211..395
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 407..680
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 752..841
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 96063 MW; 40DE5FC272405990 CRC64;
MESITGNDAN IGSARGDAST TSGDVASDLT GGGGSSGSAL VMTLLPALVY AAFWISLFLI
FRRTQRRWYA PRSYLPDIHE HQRSPELPSG WVNWLGTFLR IEDNHVLHHS SLDGYLFLRF
LRVLAATCLT GCVITWPILL PLHATGGNGN TELDKLSFSN VKNPSRYYAN VIVACVYFTF
VFYVVVRESL YYANLRQAYL NSPAYASRMS SRTVLFMSVP DAYKNEKKLR QVFGDSICRT
WITSDCSKLE KMVAQRDRLA EKLETAETKL IRRANKVRTQ AIKTGEWNID MCLDCESSNP
AWSHKVKRPM HRLKFFGEKV DTIHWYRAEL AKKIEEVSNL QAKHQSGEAK QLSAIFVEFN
SQADAQVALQ TLSHHQPFHM TPRFIGVSPS EVVWSALNLS WWQRIVRRFA IQGFLAAMVI
FWSFPAAIVG AISNITYICT LIPFLGFILD LPDFIKGAIE GLLPAAALAA LMSLVPIICR
ICARRAGVPS KARVELFTQS AHFVFQVVQV FLVTTLTSAA SAATAQIVKD PLSVKDLLAQ
NLPKATNFYI SYFILQGLSM SSLALVQIVS ALVFKFVTTF FAYSPRRLFQ GWAELASLSW
GNVFPVFTNM AVIALTYSCI APLILGFAFL GLYLVYQAYR YNFLFVYDIE VDTKGLVYPR
ALQHLLTGLY LAEICMIGLC AIRGAIGPVI IMVLFLIGNI LAHMSLNDAL APLNTFLPRS
LDAEEEMLQE REDAVAAINE ERRPRAMAFW RWFHPNVYKD YAALRQKVRR NLEGVTYTPE
EMRTAYFEPC VASPPPTLWI PRDKWGFSNH EVIETDSIIS ITDEGAHLDD KNKIVWDKYD
PHLPLRELKT LY
//
