ID   A0A1V6U0T7_9EURO        Unreviewed;       910 AA.
AC   A0A1V6U0T7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=SET domain-containing protein 5 {ECO:0000256|ARBA:ARBA00042380};
GN   ORFNames=PENSTE_c001G04877 {ECO:0000313|EMBL:OQE31820.1};
OS   Penicillium steckii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=303698 {ECO:0000313|EMBL:OQE31820.1, ECO:0000313|Proteomes:UP000191285};
RN   [1] {ECO:0000313|Proteomes:UP000191285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 24891 {ECO:0000313|Proteomes:UP000191285};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE31820.1}.
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DR   EMBL; MLKD01000001; OQE31820.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6U0T7; -.
DR   OrthoDB; 2259237at2759; -.
DR   Proteomes; UP000191285; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46402:SF2; HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5; 1.
DR   PANTHER; PTHR46402; SET AND MYND DOMAIN-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191285};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          477..835
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          860..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..875
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        896..910
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   910 AA;  105082 MW;  F0C94999AFF196B7 CRC64;
     MSDQPSTYTR STNEPTRFLT GRRGIAQQKR ANLGPGHEPD WTWVRSDGLR RFGDAFKARP
     PWTAIRSAEW PPKPGHTGKT IDFGSFVTKT DAKLAYDIWK LADDTVGDAW KNRDRQLPTS
     KAKEPGLANN VYEHLMIYSV LPLDRREAPQ VFSQQGLKKT WNVAAMIDSL KDKIIEESPI
     RGVTNWTSQA LKNELKKRDL SAAGNSKKLQ QRLIDDEVQN HCGIMPTSDL SQWGIKRKSK
     FILQPATNTE MTPLDMYTFA IHLSPYNPTY WLSRAYCHYL QGYFDLALGD AYRAQIICNT
     VEQLNERNSK DGFFTHIQHA IHQHILVYPK DEEGYWSELI TLMRKPHGIQ SMITSIHFAV
     LNIICLCLAA LNCWDDFDAY TKQLSMRAGS IFPEKFVADL RKKVSKKASR AWRRKKSKQN
     LFWFEKHQGA VSAERSYPYE NNPLEQIPEK RPLLGRLTEE IFQHQKVRED HPDVPTDTCQ
     VKMAPDRLRY GVFAKRRIRK GELIHFEEPT IRGHLPPRRL TKDRTHTKFV DDHRCEHCLD
     LVNDRERRPS IDDIRSAHPD EIDADEVPYC TCLRHWLRNP HDKKGLMFCP SDSKETSCLQ
     IAYDLYHYDG CGRNWTWLYD TMRPNVWTWS GMQHISHSNE VHGTHLSLLL RSVAETTLLR
     REDYDEPGLA PYEIDEILIL NGNSKSWRSS WFPFTMSANI IVPFDIFSFL GINIFRDFSF
     DTWALQIIMR KLLVNAVPWD MKRRGNIRTV LTTDKEKILD SPAQQVRRLM NGYSLGEWDP
     SFLNLYLFSG LSLFNHTCAG KENAEWAYDS QVLNRVIVWA KKNIEVGEEI RIRYQNDTVD
     SRGDAARLFG GPCLCPHKSK HNTVDESESD EESTSKETSV SLLMSNVALS DDSSESEDGW
     LARAEGKTES
//