ID A0A1V6U3X4_9EURO Unreviewed; 266 AA.
AC A0A1V6U3X4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 7 {ECO:0000256|ARBA:ARBA00020631, ECO:0000256|RuleBase:RU364060};
GN ORFNames=PENFLA_c001G08711 {ECO:0000313|EMBL:OQE32960.1};
OS Penicillium flavigenum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=254877 {ECO:0000313|EMBL:OQE32960.1, ECO:0000313|Proteomes:UP000191342};
RN [1] {ECO:0000313|Proteomes:UP000191342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 14082 {ECO:0000313|Proteomes:UP000191342};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|ARBA:ARBA00011837, ECO:0000256|RuleBase:RU364060}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364060}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC {ECO:0000256|ARBA:ARBA00009994, ECO:0000256|RuleBase:RU364060}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE32960.1}.
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DR EMBL; MLQL01000001; OQE32960.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6U3X4; -.
DR STRING; 254877.A0A1V6U3X4; -.
DR OrthoDB; 11599at2759; -.
DR Proteomes; UP000191342; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.140.1520; -; 1.
DR Gene3D; 6.10.140.200; -; 1.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR009244; Mediatior_Med7.
DR InterPro; IPR044888; Mediatior_Med7_sf.
DR PANTHER; PTHR21428; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7; 1.
DR PANTHER; PTHR21428:SF11; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7; 1.
DR Pfam; PF05983; Med7; 1.
DR SUPFAM; SSF140718; Mediator hinge subcomplex-like; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364060};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364060};
KW Reference proteome {ECO:0000313|Proteomes:UP000191342};
KW Transcription {ECO:0000256|RuleBase:RU364060};
KW Transcription regulation {ECO:0000256|RuleBase:RU364060}.
SQ SEQUENCE 266 AA; 30670 MW; BDD223035FB72BE3 CRC64;
MADTNQQRAV TAAFALPPPL WKHFTRENLD RLEQIKTEAS KYENGHPNHK KELTPSELRA
LDLPPELRFL VSPKTPTGEY SVFGEQQTLS TKLPSLEEQG VKQLYPDPVT DSEQDPSKPS
LPLDHAYYIS KISKSILLNF LEFVGILSVS PEQFESKVDD MRNLFINAHH LVNLYRPHQA
RESLIMMLEE QLARSKEKIN RIDKARQISR LPWASLKQKV NRPVLQRRQK VLANRKKMLV
ALLKIISWRG ISWIKTTKQA GPMTVY
//
