ID   A0A1V6U779_9EURO        Unreviewed;       415 AA.
AC   A0A1V6U779;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=O-methyltransferase domain-containing protein {ECO:0000259|Pfam:PF00891};
GN   ORFNames=PENCOP_c021G07791 {ECO:0000313|EMBL:OQE34338.1};
OS   Penicillium coprophilum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=36646 {ECO:0000313|EMBL:OQE34338.1, ECO:0000313|Proteomes:UP000191500};
RN   [1] {ECO:0000313|Proteomes:UP000191500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 31321 {ECO:0000313|Proteomes:UP000191500};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE34338.1}.
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DR   EMBL; MDDG01000021; OQE34338.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6U779; -.
DR   OrthoDB; 1067404at2759; -.
DR   Proteomes; UP000191500; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF1; HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191500};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          253..389
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   415 AA;  46306 MW;  0808166D396C0162 CRC64;
     MAAENSLYAT FPVDLGISTR PNHNEAVPDL LKEVIEGVNN LATGTDENRK DVVVKCRALV
     GALETPRETM VDHCWGQFGA ISAIAFGVDS GLWVLMAQNG DRPQRVASLA IGLGVDPRLL
     SRLMRHVGAM GLLIEVGEDE YRPTNFTKAL SIPQIGHGYI GFTASTGAAT LKFHEFARKR
     DWANPTDNQD TSLMYAYGTD KDIFSWVNDL GYGKHLNDYL GGYNLGRPWW IDPSVYPVKE
     RLIDGADISP DAPFLVDIGG NVGHDLERFR SRFPNTPGRL ILQDLPLMIR QIKDLDPAIL
     RMEYDFHDEQ PIKCESPEPT LQPFLSILDD VFDTIKEAMK PGYSRLLINE NVVPQIGAHW
     ETTGLDMMML TLFSGEERTS TAWYELIERR AGLKIVKIWG AGKGVESVIE CVKER
//