ID A0A1V6UR78_9EURO Unreviewed; 950 AA.
AC A0A1V6UR78;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENCOP_c005G00926 {ECO:0000313|EMBL:OQE40921.1};
OS Penicillium coprophilum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=36646 {ECO:0000313|EMBL:OQE40921.1, ECO:0000313|Proteomes:UP000191500};
RN [1] {ECO:0000313|Proteomes:UP000191500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 31321 {ECO:0000313|Proteomes:UP000191500};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE40921.1}.
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DR EMBL; MDDG01000005; OQE40921.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6UR78; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000191500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF5; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..187
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 210..376
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 387..670
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 821..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 106756 MW; 3357BE2415342D36 CRC64;
MDIHRLSLNA RTDGADTFLE LIANPFRSAF TVTAIWASLG TSIGVTVLLA LLFSLIRPRH
SLVYAPKVKH ADLKHTPPPV GKGFFAWVKP VINTREAQLI ETVGLDAAIF LRFTKMCRNI
FIFLSIIGCL VMIPVNITQS KNSTDSSASG AFNMMTPLNI TNPTAIWSQV VCAWAFDLIV
VFFLWRNYRA VRNLRRQYFQ SSEYQRSLHA RTLMITDIPP GDRTDEGILR LTDKVNPTAA
LPRAAIGRNV RDLPRIIKEH EEVVRKLESV LAKYLKNPDR LPAKRPTLRP PRKERNQLAS
GRVDAIDYLS VRIRVLEEEI KHGRASIDRR NAMPYGFASW DNIEHAHAVA WNARRKHPEG
TTIDLAPRPS DLIWENLPLT KSARKWKRLV NFVWVTCLTV VWIVPNGLIA IFLSNLSNLG
LVWPAFQTSL SANPNVWAAV QGIASPALTS LVYLALPIIF RRLSIQGGSK TKTSRERHVL
GHLYAFFVFN NLIVFSLFSA AWYFVSFVID KTNNHEDAWQ AILESRMYAK LVSALCTVSP
FWVTYLLQRN LGAAIDLVQL VTMVWVWFAK TFLAPTPRQA IEWTAPPPFD YASYYNYFLF
YATVAFCFAT LQPIVLPVTA LYFGVDAMLK KYLLMYVFIT KNESGGAFWR VLFNRLIFAT
ILANVIIALV AKSSGTWTMV FCVVPLPFLM LGFKLYCMKT FDSDCEFYNR GNLSDAEALG
VNKSDKKASD RLNTKFGHPA LYKPLLTPMV HAKAAAALKD IYQGRLDQGD TGGEYSDIAM
NPMLASQPGK SAEPSPFEVV PESHLDFSYY KDRADFRDEF GGGIYGRPED LMTERSHTPR
STLRGEWSPG SSRASSPAPS LPSMPLNIHN GYENPDPTGL IHPAFRVPLS RGDSGNSMDE
AESRLLTHAQ TPGQADITNP LDRWRTGGYG PVGQDDEPAY APYDAYRPHR
//