ID   A0A1V6UUP4_9EURO        Unreviewed;       701 AA.
AC   A0A1V6UUP4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=geranylgeranyl diphosphate synthase {ECO:0000256|ARBA:ARBA00012382};
DE            EC=2.5.1.29 {ECO:0000256|ARBA:ARBA00012382};
GN   ORFNames=PENCOP_c004G07505 {ECO:0000313|EMBL:OQE42161.1};
OS   Penicillium coprophilum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=36646 {ECO:0000313|EMBL:OQE42161.1, ECO:0000313|Proteomes:UP000191500};
RN   [1] {ECO:0000313|Proteomes:UP000191500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 31321 {ECO:0000313|Proteomes:UP000191500};
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
CC   -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004721}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the FPP/GGPP synthase
CC       family. {ECO:0000256|ARBA:ARBA00038363}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the terpene synthase
CC       family. {ECO:0000256|ARBA:ARBA00038372}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQE42161.1}.
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DR   EMBL; MDDG01000004; OQE42161.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6UUP4; -.
DR   STRING; 36646.A0A1V6UUP4; -.
DR   OrthoDB; 5770at2759; -.
DR   Proteomes; UP000191500; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046165; P:alcohol biosynthetic process; IEA:UniProt.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   GO; GO:0043386; P:mycotoxin biosynthetic process; IEA:UniProt.
DR   Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR033749; Polyprenyl_synt_CS.
DR   PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR12001:SF72; THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   Pfam; PF19086; Terpene_syn_C_2; 1.
DR   SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR   SUPFAM; SSF48576; Terpenoid synthases; 2.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE   3: Inferred from homology;
KW   Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191500};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          116..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   701 AA;  79847 MW;  4844EAA37BFC75A9 CRC64;
     MNPSTTEPDD IWINSKPVDL TSERPPDCFT SRAVRINEYD DVMNLHTTNA TNDWTAAICD
     DADRKVEHAF SPMGNVSSLI FPECSPEKAH ILAYFTQLSF IHDDITDVLS SKNAKKANKN
     SSRALDPKDI QHSPSERGEA MKKLLSQKFV EMIDMDTDEG QEFVKRLKVW AGDEIGLKNP
     QTIECVDEYL RFRQLDGGLR VYWHWLAFSH GDSFTQADWN SIEDLLTSAD KVLIWTNDYF
     SWPRERFYEQ GRIANVIELY MRTKGIAEEE AKQKTKEEIL QGEHRFHDMC VERFAREPNL
     PRHIKRLLRV AEIAMGGYNY WASTCPRLNS WKEQGPTAEI VFHETEDDKI LNSTEEAQLV
     KPVKINQTQE NAKIQFQPSV SHLDSAACTS ALDDSALLAP ARYIESLSSK NTVSKLADAF
     NVWMHVSPKP LAAIKDAIND LHNSSLILDD VQDSSPLRRE RTATHLIFGA AQTINSATYM
     VVRAAKIINA LGTPQMMTAL LQNLETLFIG QSWDISWRNN FHCPTESEYL DMVDKKTGAS
     LTMMVELMQA KGKIMPFSYR LSPLARRIGR WYQIRDDYMN LQGADYSKQK GFCEDLDEGK
     LSYPIVRCCQ KDVTIKNIIL GIFRQMRMTN TKMMRESKLQ ILDLMSSVMA LEDTFGYLQQ
     LQQEIEQEIG EIEALTGKSN PELLLVVKAL GVIPKAGGKE H
//