ID A0A1V6V8L6_9EURO Unreviewed; 721 AA.
AC A0A1V6V8L6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DUF726 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENCOP_c001G07857 {ECO:0000313|EMBL:OQE46996.1};
OS Penicillium coprophilum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=36646 {ECO:0000313|EMBL:OQE46996.1, ECO:0000313|Proteomes:UP000191500};
RN [1] {ECO:0000313|Proteomes:UP000191500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 31321 {ECO:0000313|Proteomes:UP000191500};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE46996.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MDDG01000001; OQE46996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6V8L6; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000191500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0072330; P:monocarboxylic acid biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF22; DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860); 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191500};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 276..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 79031 MW; 441F7333E69AB48F CRC64;
MFKNLKEKHG GFFESKQSNA SDSDRGQDLS SILDRSQRGD LTVLVAEVAE SMRVRILELY
EHTNPKDDSP NRSSPRSSPE AGRDEDTPRL PPKPQRKPLP GNNRSPRQGS TNKPLAPQAK
VTALSAFEDW RDSVLLRVGT VVNKDDNKQG EKEGQEELQN VSKSNDLPLD EDQDRMAKLQ
EIYHPVETPL AKLPKATRLL ILHSLLLLML SLEHYSAYSR VLMLNVTSSL NIDINLLNQD
EVSVARGLLQ TALALSADQD TKEQPKKDDS MRKWKVGLAS VAGAALIGLT GGLAAPLVAA
GLGTVMGGLG LGATAAAGLL GTLAGSSVVV GGLFGAYGGR MTGRMMEKYA REVDDFAFIP
IRGERRRNVK EKESAQQDHR LRVTIGVTGW VKEESNFVIP WRVIGTDSEV FGLRWEMEPL
MNLGNAISAL VTSAAWSVAG REVLARTVFS TIMSAVMLPL GLMKVAGVVD NPFSVAKARA
DKAGEVLADA LINKAQGERP VTLMGYSLGS RLIFSCLQSL ERRNAYGLVE TVILMGSPTP
SDKEDWQKIR SVVSGRVVNV FSENDSVLAF LYRTSSLQLG VAGLQPVEGV PGVENVNVSE
MISGHLRYQF LLGRILTLIG LQDLDPSEIE REEAALACED ERLEKERLEN EREAGVKDRE
SSSARETLNS EHGFGEDERL QKKVEAQTQE NMTTHRIEML DMDDDDYSTP LKEDPSKHPA
L
//