ID A0A1V6WWD0_PENNA Unreviewed; 566 AA.
AC A0A1V6WWD0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PENNAL_c0176G06658 {ECO:0000313|EMBL:OQE67189.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE67189.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE67189.1}.
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DR EMBL; MOOB01000176; OQE67189.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6WWD0; -.
DR STRING; 60175.A0A1V6WWD0; -.
DR OMA; EREWNAS; -.
DR OrthoDB; 2206489at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 1..109
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 319..466
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OQE67189.1"
SQ SEQUENCE 566 AA; 64117 MW; D4B12C465D73C57D CRC64;
TAPLVNAGLA QGSPLSPILF AFFNADLVDQ PVDSQGGASA FIDDYFRWRV GGSVQENLSK
IQSEDVPRIE EWARRTGSCF AAEKTELIHL TRKKGEHREG QIIFDGTDVK PSPTAKLLGV
VFDQRLRWKE HVQQVIKRAT KTAIALSGLR HLRPEQMRQL YQACVAPIVD YASTVWHDPL
RDKVHIRHLN TVQRNVLIRI LSAFRTVATA TLEVEAYILP THLRLRHRAQ RTIARLHTLP
RDHPIWSALF RAQNRRNNVG SYARFPLAEA LKTMEVDRLN ELETIDPRPL PPWRPNAFME
IELEHDREIA RERAEDARNT SDIVVYSDAS GREGHLGAAI VALNDNDEVI ESQQVQVGSM
ERWSVHVAGL MGIFYAISMV FKLAHQCASI ENHMHITATI LCDSRSALQA IQNVKIRSGQ
RIVHAILQAA TEVQAGHVSL RLQWMPGHCE IVGNEAADRL AKEAAQPGKS HPFRPLLTRE
YAFIRGKIQA QWEQEWKSSI KGAHLRKVDG ALPARHTRKL YGSLPRNRAY LLTQLRTGHI
WLSTYAKKFG FRDNDRCDSR HNGNAK
//
