ID A0A1V6XQQ9_PENNA Unreviewed; 1063 AA.
AC A0A1V6XQQ9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=PENNAL_c0061G08944 {ECO:0000313|EMBL:OQE77484.1},
GN PNAL_LOCUS9421 {ECO:0000313|EMBL:CAG8281876.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE77484.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|EMBL:OQE77484.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|EMBL:OQE77484.1};
RA Nielsen J.C., Nielsen J.;
RT "Uncovering the secondary metabolism of Penicillium species provides
RT insights into the evolution of 6-MSA pathways.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
RN [3] {ECO:0000313|EMBL:CAG8281876.1}
RP NUCLEOTIDE SEQUENCE.
RA Branca A.L. A.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE77484.1}.
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DR EMBL; CAJVNV010000619; CAG8281876.1; -; Genomic_DNA.
DR EMBL; MOOB01000061; OQE77484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6XQQ9; -.
DR STRING; 60175.A0A1V6XQQ9; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR Proteomes; UP001153461; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..45
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 67..108
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 128..169
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 746..980
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 422..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 115093 MW; 1AE073725F584225 CRC64;
MHIIKPVWLT HGGERKDFEV YSCDVSPDGK RLVTAAGDGY VRIWSTDAIY GTGTPELEGK
PKQLASMSNH SGTIHTVRFS PNGKYLASGA DDKIVCVYTL DANPPTHSST FGTDEAPPVE
NWRTIRRLIG HDNDVQDLGW SFDSSILVSV GLDSKVVVWS GHSFEKLKTI AIHQSHVKGI
TFDPANKYFA TASDDRTVRI FRFTSPAPNS SSHDHMNNFV LEQTITAPFA NSPLTAYFRR
CSWSPDGMHI AAANAVNGPV SSVAIINRGS WDGDINLIGH EAPVEVCSFS PRLYATEPPN
KKQADGQPVP QHHITVIACA GGDKSLSIWI TSNARPIVVA QEMAAKAISD LAWTPDGKCL
FATALDGTIV AVMFEDGELG WATEMEENEK SLTKFGTNRK GAGITETTDS LLLEEKSKAG
EIKHVEGRMG ALMGDGAEPT TNGDKAPQPS NGTTPARGPS PAPEVTKTQT NGTPATPTTT
ESDKPDPYKA KLERLKQRPT YTKEGKKRIA PLLVSGAGAG ESSLPQARLM ASVSNQVKAD
APTTIVDLSK PFDGLPKGGL TALLLGNKRK LAQIEGDEDG GVEKRVALAS QNGATPIMAN
TPDGLLPAQV QSATTGQQPT PEFIRPAVTN PCMSVSQLRL AVPKIRTQIL RALDSSGKPT
EQPVPGTDSG SAKSRVDVIF EVRNPSPASL TGRAVDREPV RLTLFRGDQP LWQDFLPRTV
LLVTGNQSMW AAGCEDGSIY LWTPAGRRLV SALVLEAQPV ILECNGPWIL CISSVGMCYV
WNVKHLSSPH PPVSLQPVLD AAIHTLGANP TAAPAITEAR INSEGRVVVS LSNGEGYSYS
PSMFTWQRIS EAWWAVGSQY WNTTDAPVSN LQATDAQQDT KDAKAAVAAG IIPWLERNTT
NETLLRGRAY FLQRLIKVLL SREGYETFES SVSIAHLENR LAAALSLGAK EEFRLYLSMY
AKRIGAEGLK LKVEELLKGL IGGIFEDEDD ASERVLKLQA NEREGRNWRE GSDDLCGWPR
ETLLKEVILA LGKHRDLQRV TVPYAKLLDM VDTTSEHGDA MDL
//
