ID A0A1V6XWA1_PENNA Unreviewed; 1015 AA.
AC A0A1V6XWA1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENNAL_c0051G07214 {ECO:0000313|EMBL:OQE79432.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE79432.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE79432.1}.
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DR EMBL; MOOB01000051; OQE79432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V6XWA1; -.
DR STRING; 60175.A0A1V6XWA1; -.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691}.
FT DOMAIN 219..354
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 792..947
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 360..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..618
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 112366 MW; 478C94D47377E71A CRC64;
MKMATIQAIE ARSVHQIQSG QVIVDLCSVA KELVENSLDA GATTIEVRFK NNGLDLIEVQ
DNGSGISPEN YENVALKHYT SKLSSYDDLS SLHTFGFRGE AISSLCALAD FHIVTAQEKQ
VPRANRLDFE QSGKLRKTQI VAGQKGTTAS AEGIFKRLPV RRRELEKNIK REYGKVLNLL
HAYACISTGV RFSVRNTVGK TRNVVVFSTN GNKTTKENIA NVYGAKTLSA LISLDLELEF
ETSAATKRVG DDQLSKIQVR GHISRPVFGE GRQTPDRQMF FVNSRPCGLP QIQKAFNEVY
KSFNVSQSAF IFADFQMDTN AYDVNVSPDK RQILLHDAGA MIQSLKVSLA QLFEDADQTV
PQSSVRSKPL PKQQPLAPLP GFVTARELSE SGEFRRPSQD RTKEGSVETP GASQQSALQR
FTSSEAGMGS AQATPSPARS MRTPRAATNR SLMSTPAPSE LETPTAAISD DELFVQGGAQ
EEPEPTAVSD EPSSQPPIPD ETPSRTRGDP EEIPNVVQNA FDRMRPRREP AELATITIGN
RTITSMVGSG PPRKRVSADP PLMKEPPRRK RRIHTPSRPN IFGEHMKSFA APGSQPHEAA
EEGEDDEDED EEASASEVGQ VEEDGSNLLS EIEDTQGAEQ EAEGEGSPPP EDVDYVPDQG
ANQLETENTE AKDKDTAADE NLDEAQKKAQ EEATVQRLIH EAEETAMLTQ ENSAKRAKKM
SKGAAHRDAT IQLVGTVDGS ISRLQSQFVT FQKTLQAGMK KTKEEATDLG QKTAEDKLSL
TVSKNDFAQM RIIGQFNLGF IIAVRPGEDH DELFIIDQHA SDEKFNFERL QAETVVQNQR
LVRPQRLDLT AVEEEVVLEN RAALEKNGFL VTVDESGDEP IGRRCQLVSL PLSKEVVFGV
RDLEELIVLL SESISTSNEL SVPRPSKVRK MFAMRACRSS IMIGKTLTSR QMERVVQNMG
TIDKPWNCPH GRPTMRHLMS LGQWDEWNEF EETEGLDPWK QYLEEEDEED EEDGE
//
