ID A0A1V6Y9S4_PENNA Unreviewed; 1489 AA.
AC A0A1V6Y9S4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=PENNAL_c0029G08275 {ECO:0000313|EMBL:OQE84074.1};
OS Penicillium nalgiovense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=60175 {ECO:0000313|EMBL:OQE84074.1, ECO:0000313|Proteomes:UP000191691};
RN [1] {ECO:0000313|Proteomes:UP000191691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 13039 {ECO:0000313|Proteomes:UP000191691};
RX PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA Frisvad J.C., Workman M., Nielsen J.;
RT "Global analysis of biosynthetic gene clusters reveals vast potential of
RT secondary metabolite production in Penicillium species.";
RL Nat. Microbiol. 2:17044-17044(2017).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQE84074.1}.
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DR EMBL; MOOB01000029; OQE84074.1; -; Genomic_DNA.
DR STRING; 60175.A0A1V6Y9S4; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000191691; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 3.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000191691};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1489
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012731926"
FT TRANSMEM 1364..1383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1410..1433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..690
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 725..1351
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1489 AA; 167498 MW; 5AF267B9EEB935A9 CRC64;
MIPRWLLLTL SLLLVWASHP AAAKGNEPNI VTHELDAPPA DLFYFHGTNT ILYRNRKSLT
AHVSFDGGEE WETVRGNDGT IEGTVDLIWR HPFDDNRAYI LGENGKHWIT TDQAKTWKPF
QVDVVPFASM RSFPLEFNGW DPKKVIFMGL DCTILGCIPQ TFYTTDDFET VKPLREMTLQ
CMWAASRPQF ALDLDMPKST GDRILCVVPG LKGPFEHTRT ERLIYSDSFF KDDAEDTEAK
LDHGKPLSGV SLQIRSVSKY IVARLQSRGT QEQALYVSDD SNVWHRAEFG KHRIEEDAYT
ILESTNYSIQ IDVQTTWHDN RMGSLFSSNS NGTYFTQNIE HTNEDMNGLV DFEKVTGIHG
ITIVNTVKNW EEAKKSDSNK KKLISSISFD DGRTFQPLKA DKDELHLHSM TTYAALHEMP
LPDHRMFSSP APGLVMGVGN TGGHLEDYSK GDLYVSDNAG LTWRRALKGP HRYEFGDQGG
VITAVLDSSH TDKVQFSIDH GKEWESISLG QKIRPLFLIS TPDSTSLKFL LVGTSSDDAT
KSLMFFIDFD DLHERECGSG DLEEWTARLN EKGEPDCLMG QKQFFQRRKA NADCFIKKEF
AISGPEFEPC KCSAEDFECD YNFVRSEDRK ECVPAVPLTP PAGKCKDPSD KYMGPSGWRL
IPGNACIREG GEDLEREIER SCSNVTGPPL ITDGKPRAGK PQTISAKRTN YFYLERQASN
NGVDETIMML TDKYELHVSR DHGRNWKQIH PDEKFTEMVQ HPYFSDAAFF LTDSKRVYYT
INHGDSFHFF DAPSVPTKES IRTLAFHEKF QDSLIWIGHK DCEGRNCRSQ AYVTDKRGAS
WEPMLIGIAD GGCNFGYQEG RNNSEKLVIC EQYKDEEKNN NRQLVISDDY FSTMEVKFDN
IARSATKNGF EVVAWYEGDQ KEYLNASVSV DGRTYANAHF PFNIKVPQYT VLPSSPHALF
LLVMVNGGGD RSFGSLVKSN SNGTYFVQSL EGLNVNDRGY TDYDELQGLE GVAIANVVSN
REEVLNKGAA KKLRTMITHN DGGQWMLLAP PSKDVDGKNF DCSVTEGRGT EKCALHFHGY
TERRDYRDTL YSGSAIGLML ALGNVGEHLT SASESDTFLT RDGGISWMQV KKGQYMWEFG
AAGSIVVLVS DRKATNVVHY TLDEGMSWHD FQFAEKELVI DDISTVPSDT SKNFLLWGMD
GGKRVTITLD FSGIWSRDCD DDENDYYNWA PTHPFQEENC IFGHVEEYHR KKPAAECWNA
WREPHIHSIG RNCTCTRADF ECDYNYEIQT DGSCGLVPGL QPQDHIAQCS QDPDKVEYWE
PTGYRRIPQT TCQGGHLLDQ DVSKPCPNKE EEYQKKHGIS GTGLFFAIVT PIAVAVAVGW
YAYTHWDGKF GQIRLGDSGA SQSWLSRDSV LVAVPVAIIA GIVAVAQSLP LLVRSLARSS
SGLFGRRGTQ RPYATRGSFA ARRGDYSSVV DDEDELLGAD DFDDEEDQA
//
